Layer 6 Continuous Stuttering Neurogliaform Cell (4)

Model Type:
Cell
Neurolex IDs: Neocortex Layer 6
Keywords: continuous stuttering,Layer 6,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, neurogliaform, biophysical, continuous stuttering neurogliaform cell, Realistic Network, Neuron or other electrically excitable cell, Synapse, Spatio-temporal Activity Patterns, Detailed Neuronal Models
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000995
cSTUT189_L6_NGC_d2971f01cf_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCH000115
StochKv_deterministic.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000995
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Fast Spikers (FS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -76.05 mV
Rheobase Current Interval (0.11261, 0.11398] nA
Threshold Current Interval (0.29297, 0.35156] nA
Bias Current (to -70.00 mV) 0.0239 nA
Testing Temperature 34.0 °C
Stability Interval [-0.9375, 15.0] nA
AP 1-2 Amplitude Drop 5.3835 mV
AP 1 Steady State Amplitude Change 10.9974 mV
AP 1 Amplitude 68.6778 mV
AP 1 Width at Half Height 0.7700 ms
AP 1 Width (Peak To Trough) 4.2600 ms
AP 1 Rate of Change Peak to Trough -20.1742 mV/ms
AP 1 AHP Depth 17.2641 mV
AP2 Amplitude 63.2944 mV
AP2 Width at Half Height 0.7900 ms
AP 2 Width (Peak to Trough) 4.5100 ms
AP 2 Rate of Change Peak to Trough -18.2191 mV/ms
AP 2 AHP Depth 18.8735 mV
AP 1-2 Amplitude Change Percent -7.8387 %
AP 1-2 Half Width Change Percent 2.5974 %
AP 1-2 Rate of Change Peak to Trough Percent Change -9.6911 %
AP 1-2 AHP Depth Percent Change 9.3227 %
Input Resistance 353.9660 MΩ
AP 1 Delay Mean 6.2900 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 23.9900 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 18.5650 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -9.5238 %
Steady State Accommodation Mean -9.5238 %
Accommodation Rate to Steady State -0.0112 %/ms
Accommodation at Steady State Mean -21.3944 %
Accommodation Rate Mean at Steady State 2730.4539 ms
ISI CV 10.0852
ISI Median 19.2500 ms
ISI Burst Mean Change 9.7740 %
Spike Rate (Strong Stimulation) 87.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 2.8700 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 12.9200 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 10.8650 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2115.8400 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 38.0403 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 3387.44 µm2
Number of Stems 6.0
Number of Bifurcations 58.0
Number of Branches 121.0
Overall Width 114.005 µm
Overall Height 149.531 µm
Overall Depth 86.04 µm
Average Diameter 0.716829 µm
Total Length 2370.7 µm
Total Surface 5131.43 µm2
Total Volume 1716.05 µm3
Max Euclidean Distance 142.154 µm
Max Path Distance 175.976 µm
Max Branch Order 8.0
Average Contraction 0.962003
Total Fragmentation 1635.0
Partition Asymmetry 0.445327
Average Rall's Ratio 1.97923
Average Bifurcation Angle Local 27.7772 °
Average Bifurcation Angle Remote 45.179 °
Fractal Dimension 1.00991
Complexity Summary
Relative Complexity 726.28 HH
State Equations 1658
Optimal Time-Step 0.00539 ms
Model Size
Sections 121
Compartments 149
State Equations 1658
Variable Time-Step Complexity
CVODE Steady State Step Frequency 31345 Hz
CVODE Steps Per AP 112
CVODE Benchmark Run Time 726.28 HH
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