Layer 6 Continuous Stuttering Neurogliaform Cell (3)

Model Type:
Cell
Neurolex IDs: Neocortex Layer 6
Keywords: continuous stuttering,Layer 6,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, neurogliaform, biophysical, continuous stuttering neurogliaform cell, Realistic Network, Neuron or other electrically excitable cell, Synapse, Spatio-temporal Activity Patterns, Detailed Neuronal Models
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000994
cSTUT189_L6_NGC_a138b95b10_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCH000115
StochKv_deterministic.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000994
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Fast Spikers (FS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -76.10 mV
Rheobase Current Interval (0.11536, 0.11673] nA
Threshold Current Interval (0.29297, 0.35156] nA
Bias Current (to -70.00 mV) 0.0245 nA
Testing Temperature 34.0 °C
Stability Interval [-0.9375, 15.0] nA
AP 1-2 Amplitude Drop 5.8990 mV
AP 1 Steady State Amplitude Change 12.6967 mV
AP 1 Amplitude 68.1117 mV
AP 1 Width at Half Height 0.7900 ms
AP 1 Width (Peak To Trough) 4.3000 ms
AP 1 Rate of Change Peak to Trough -19.7663 mV/ms
AP 1 AHP Depth 16.8834 mV
AP2 Amplitude 62.2127 mV
AP2 Width at Half Height 0.8200 ms
AP 2 Width (Peak to Trough) 4.5600 ms
AP 2 Rate of Change Peak to Trough -17.7607 mV/ms
AP 2 AHP Depth 18.7761 mV
AP 1-2 Amplitude Change Percent -8.6608 %
AP 1-2 Half Width Change Percent 3.7975 %
AP 1-2 Rate of Change Peak to Trough Percent Change -10.1465 %
AP 1-2 AHP Depth Percent Change 11.2107 %
Input Resistance 346.6483 MΩ
AP 1 Delay Mean 6.3000 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 24.0000 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 18.5700 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -9.5238 %
Steady State Accommodation Mean -9.5238 %
Accommodation Rate to Steady State -0.0117 %/ms
Accommodation at Steady State Mean -21.0843 %
Accommodation Rate Mean at Steady State 2376.9253 ms
ISI CV 9.7560
ISI Median 19.2500 ms
ISI Burst Mean Change 9.8305 %
Spike Rate (Strong Stimulation) 87.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 2.8700 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 12.8900 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 10.8300 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2114.2000 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 38.5427 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 3387.44 µm2
Number of Stems 6.0
Number of Bifurcations 58.0
Number of Branches 121.0
Overall Width 116.377 µm
Overall Height 148.563 µm
Overall Depth 94.34 µm
Average Diameter 0.716829 µm
Total Length 2432.83 µm
Total Surface 5247.58 µm2
Total Volume 1732.25 µm3
Max Euclidean Distance 105.231 µm
Max Path Distance 136.582 µm
Max Branch Order 8.0
Average Contraction 0.963195
Total Fragmentation 1635.0
Partition Asymmetry 0.445327
Average Rall's Ratio 1.97923
Average Bifurcation Angle Local 28.8181 °
Average Bifurcation Angle Remote 45.9768 °
Fractal Dimension 1.00976
Complexity Summary
Relative Complexity 680.51 HH
State Equations 1614
Optimal Time-Step 0.00539 ms
Model Size
Sections 121
Compartments 145
State Equations 1614
Variable Time-Step Complexity
CVODE Steady State Step Frequency 32087 Hz
CVODE Steps Per AP 90
CVODE Benchmark Run Time 680.51 HH
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