Layer 6 Continuous Stuttering Nest Basket Cell (5)

Model Type:
Cell
Neurolex IDs: Neocortex basket cell
Neocortex Layer 6
Keywords: continuous stuttering,Layer 6,Fast-spiking, interneuron, GABAergic, inhibitory, neocortex, rat, somatosensory cortex, nest, basket, biophysical, continuous stuttering nest basket cell, Realistic Network, Neuron or other electrically excitable cell, Synapse, Spatio-temporal Activity Patterns, Detailed Neuronal Models
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000991
cSTUT189_L6_NBC_df448fd9b1_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCH000115
StochKv_deterministic.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000991
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Fast Spikers (FS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -75.05 mV
Rheobase Current Interval (0.21217, 0.21423] nA
Threshold Current Interval (0.46875, 0.52734] nA
Bias Current (to -70.00 mV) 0.0426 nA
Testing Temperature 34.0 °C
Stability Interval [-1.5625, 15.0] nA
AP 1-2 Amplitude Drop 5.0289 mV
AP 1 Steady State Amplitude Change 5.9086 mV
AP 1 Amplitude 77.8662 mV
AP 1 Width at Half Height 0.5600 ms
AP 1 Width (Peak To Trough) 2.9000 ms
AP 1 Rate of Change Peak to Trough -34.2978 mV/ms
AP 1 AHP Depth 21.5973 mV
AP2 Amplitude 72.8373 mV
AP2 Width at Half Height 0.5800 ms
AP 2 Width (Peak to Trough) 2.9600 ms
AP 2 Rate of Change Peak to Trough -31.9618 mV/ms
AP 2 AHP Depth 21.7696 mV
AP 1-2 Amplitude Change Percent -6.4584 %
AP 1-2 Half Width Change Percent 3.5714 %
AP 1-2 Rate of Change Peak to Trough Percent Change -6.8108 %
AP 1-2 AHP Depth Percent Change 0.7980 %
Input Resistance 170.1018 MΩ
AP 1 Delay Mean 5.9000 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 26.6400 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 21.5650 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -5.5556 %
Steady State Accommodation Mean -5.5556 %
Accommodation Rate to Steady State -0.0071 %/ms
Accommodation at Steady State Mean -24.2184 %
Accommodation Rate Mean at Steady State 4643.5210 ms
ISI CV 31.7985
ISI Median 23.1750 ms
ISI Burst Mean Change 7.9556 %
Spike Rate (Strong Stimulation) 76.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 2.3500 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 13.1400 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 11.8350 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2129.0100 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 91.5149 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 19673.4 µm2
Number of Stems 10.0
Number of Bifurcations 32.0
Number of Branches 73.0
Overall Width 208.485 µm
Overall Height 413.012 µm
Overall Depth 214.56 µm
Average Diameter 0.957724 µm
Total Length 3935.38 µm
Total Surface 10131.2 µm2
Total Volume 7850.05 µm3
Max Euclidean Distance 338.594 µm
Max Path Distance 378.158 µm
Max Branch Order 5.0
Average Contraction 0.961082
Total Fragmentation 2742.0
Partition Asymmetry 0.458333
Average Rall's Ratio 1.07705
Average Bifurcation Angle Local 10.1396 °
Average Bifurcation Angle Remote 60.8772 °
Fractal Dimension 1.00943
Complexity Summary
Relative Complexity 575.36 HH
State Equations 2197
Optimal Time-Step 0.00776 ms
Model Size
Sections 72
Compartments 198
State Equations 2197
Variable Time-Step Complexity
CVODE Steady State Step Frequency 17605 Hz
CVODE Steps Per AP 266
CVODE Benchmark Run Time 575.36 HH
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