Layer 6 Continuous Stuttering Large Basket Cell (2)

Model Type:
Cell
Neurolex IDs: Neocortex basket cell
Neocortex Layer 6
Keywords: continuous stuttering,Layer 6,Fast-spiking, interneuron, GABAergic, inhibitory, neocortex, rat, somatosensory cortex, large, basket, biophysical, continuous stuttering large basket cell, Realistic Network, Neuron or other electrically excitable cell, Synapse, Spatio-temporal Activity Patterns, Detailed Neuronal Models
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000983
cSTUT189_L6_LBC_0f06cad592_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCH000115
StochKv_deterministic.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000983
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Accommodating Fast Spikers (aFS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -74.98 mV
Rheobase Current Interval (0.17784, 0.17944] nA
Threshold Current Interval (0.35156, 0.41016] nA
Bias Current (to -80.00 mV) -0.0274 nA
Testing Temperature 34.0 °C
Stability Interval [-1.25, 15.0] nA
AP 1-2 Amplitude Drop 4.9460 mV
AP 1 Steady State Amplitude Change 5.5679 mV
AP 1 Amplitude 82.2321 mV
AP 1 Width at Half Height 0.5300 ms
AP 1 Width (Peak To Trough) 2.4800 ms
AP 1 Rate of Change Peak to Trough -41.3825 mV/ms
AP 1 AHP Depth 20.3964 mV
AP2 Amplitude 77.2861 mV
AP2 Width at Half Height 0.5300 ms
AP 2 Width (Peak to Trough) 2.5600 ms
AP 2 Rate of Change Peak to Trough -38.3238 mV/ms
AP 2 AHP Depth 20.8228 mV
AP 1-2 Amplitude Change Percent -6.0147 %
AP 1-2 Half Width Change Percent 0.0000 %
AP 1-2 Rate of Change Peak to Trough Percent Change -7.3912 %
AP 1-2 AHP Depth Percent Change 2.0907 %
Input Resistance 193.0508 MΩ
AP 1 Delay Mean 5.4400 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 25.7300 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 21.0750 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -5.2632 %
Steady State Accommodation Mean -10.5263 %
Accommodation Rate to Steady State -0.2212 %/ms
Accommodation at Steady State Mean -99.2049 %
Accommodation Rate Mean at Steady State 3020142.5863 ms
ISI CV 41.8435
ISI Median 22.2500 ms
ISI Burst Mean Change 7.7378 %
Spike Rate (Strong Stimulation) 79.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 2.0500 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 12.5200 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 11.5800 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2123.2400 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 105.6395 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 11083.3 µm2
Number of Stems 7.0
Number of Bifurcations 30.0
Number of Branches 66.0
Overall Width 437.742 µm
Overall Height 578.963 µm
Overall Depth 352.12 µm
Average Diameter 0.553517 µm
Total Length 6513.71 µm
Total Surface 9437.5 µm2
Total Volume 4307.09 µm3
Max Euclidean Distance 440.834 µm
Max Path Distance 486.634 µm
Max Branch Order 6.0
Average Contraction 0.9493
Total Fragmentation 2265.0
Partition Asymmetry 0.45873
Average Rall's Ratio 1.28611
Average Bifurcation Angle Local 27.6736 °
Average Bifurcation Angle Remote 49.2934 °
Fractal Dimension 1.00781
Complexity Summary
Relative Complexity 1016.79 HH
State Equations 3550
Optimal Time-Step 0.00782 ms
Model Size
Sections 67
Compartments 321
State Equations 3550
Variable Time-Step Complexity
CVODE Steady State Step Frequency 20530 Hz
CVODE Steps Per AP 207
CVODE Benchmark Run Time 1016.79 HH
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