Layer 5 Continuous Stuttering Neurogliaform Cell (4)

Model Type:
Cell
Neurolex IDs: Neocortex Layer 5
Keywords: continuous stuttering,Layer 5,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, neurogliaform, biophysical, continuous stuttering neurogliaform cell, Realistic Network, Neuron or other electrically excitable cell, Synapse, Spatio-temporal Activity Patterns, Detailed Neuronal Models
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000980
cSTUT189_L5_NGC_de4f4a2b62_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCH000115
StochKv_deterministic.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000980
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Fast Spikers (FS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -76.08 mV
Rheobase Current Interval (0.11398, 0.11536] nA
Threshold Current Interval (0.29297, 0.35156] nA
Bias Current (to -70.00 mV) 0.0243 nA
Testing Temperature 34.0 °C
Stability Interval [-1.5625, 15.0] nA
AP 1-2 Amplitude Drop 5.4227 mV
AP 1 Steady State Amplitude Change 11.7696 mV
AP 1 Amplitude 68.3253 mV
AP 1 Width at Half Height 0.7800 ms
AP 1 Width (Peak To Trough) 4.3300 ms
AP 1 Rate of Change Peak to Trough -19.7371 mV/ms
AP 1 AHP Depth 17.1365 mV
AP2 Amplitude 62.9026 mV
AP2 Width at Half Height 0.8000 ms
AP 2 Width (Peak to Trough) 4.5800 ms
AP 2 Rate of Change Peak to Trough -17.8279 mV/ms
AP 2 AHP Depth 18.7493 mV
AP 1-2 Amplitude Change Percent -7.9366 %
AP 1-2 Half Width Change Percent 2.5641 %
AP 1-2 Rate of Change Peak to Trough Percent Change -9.6732 %
AP 1-2 AHP Depth Percent Change 9.4117 %
Input Resistance 347.1034 MΩ
AP 1 Delay Mean 6.3400 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 24.1100 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 18.6300 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -9.5238 %
Steady State Accommodation Mean -9.5238 %
Accommodation Rate to Steady State -0.0122 %/ms
Accommodation at Steady State Mean -19.9882 %
Accommodation Rate Mean at Steady State 2241.2592 ms
ISI CV 9.7044
ISI Median 19.2900 ms
ISI Burst Mean Change 9.6792 %
Spike Rate (Strong Stimulation) 87.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 2.8800 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 12.9500 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 10.8700 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2107.2200 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 38.9508 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 3387.44 µm2
Number of Stems 6.0
Number of Bifurcations 58.0
Number of Branches 121.0
Overall Width 122.278 µm
Overall Height 133.826 µm
Overall Depth 122.76 µm
Average Diameter 0.716829 µm
Total Length 2416.74 µm
Total Surface 5214.36 µm2
Total Volume 1733.53 µm3
Max Euclidean Distance 96.4299 µm
Max Path Distance 125.183 µm
Max Branch Order 8.0
Average Contraction 0.963327
Total Fragmentation 1635.0
Partition Asymmetry 0.445327
Average Rall's Ratio 1.97923
Average Bifurcation Angle Local 26.9849 °
Average Bifurcation Angle Remote 45.6432 °
Fractal Dimension 1.01006
Complexity Summary
Relative Complexity 651.53 HH
State Equations 1592
Optimal Time-Step 0.00541 ms
Model Size
Sections 121
Compartments 143
State Equations 1592
Variable Time-Step Complexity
CVODE Steady State Step Frequency 32361 Hz
CVODE Steps Per AP 88
CVODE Benchmark Run Time 651.53 HH
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