Layer 5 Continuous Stuttering Neurogliaform Cell (2)

Model Type:
Cell
Neurolex IDs: Neocortex Layer 5
Keywords: continuous stuttering,Layer 5,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, neurogliaform
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000978
cSTUT189_L5_NGC_d5718b222e_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCH000115
StochKv_deterministic.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000978
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Fast Spikers (FS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -76.08 mV
Rheobase Current Interval (0.11398, 0.11536] nA
Threshold Current Interval (0.29297, 0.35156] nA
Bias Current (to -70.00 mV) 0.0243 nA
Testing Temperature 34.0 °C
Stability Interval [-1.5625, 15.0] nA
AP 1-2 Amplitude Drop 5.4678 mV
AP 1 Steady State Amplitude Change 11.5744 mV
AP 1 Amplitude 68.4701 mV
AP 1 Width at Half Height 0.7700 ms
AP 1 Width (Peak To Trough) 4.3300 ms
AP 1 Rate of Change Peak to Trough -19.7640 mV/ms
AP 1 AHP Depth 17.1078 mV
AP2 Amplitude 63.0024 mV
AP2 Width at Half Height 0.8000 ms
AP 2 Width (Peak to Trough) 4.5700 ms
AP 2 Rate of Change Peak to Trough -17.8817 mV/ms
AP 2 AHP Depth 18.7168 mV
AP 1-2 Amplitude Change Percent -7.9856 %
AP 1-2 Half Width Change Percent 3.8961 %
AP 1-2 Rate of Change Peak to Trough Percent Change -9.5240 %
AP 1-2 AHP Depth Percent Change 9.4047 %
Input Resistance 346.9300 MΩ
AP 1 Delay Mean 6.3300 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 24.0700 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 18.6050 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -9.5238 %
Steady State Accommodation Mean -9.5238 %
Accommodation Rate to Steady State -0.0109 %/ms
Accommodation at Steady State Mean -27.7430 %
Accommodation Rate Mean at Steady State 4023.1813 ms
ISI CV 9.6789
ISI Median 19.2450 ms
ISI Burst Mean Change 9.7520 %
Spike Rate (Strong Stimulation) 87.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 2.8800 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 12.9300 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 10.8600 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2106.1900 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 38.5046 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 3387.44 µm2
Number of Stems 6.0
Number of Bifurcations 58.0
Number of Branches 121.0
Overall Width 140.413 µm
Overall Height 120.439 µm
Overall Depth 97.75 µm
Average Diameter 0.716829 µm
Total Length 2425.88 µm
Total Surface 5204.92 µm2
Total Volume 1725.78 µm3
Max Euclidean Distance 131.167 µm
Max Path Distance 164.021 µm
Max Branch Order 8.0
Average Contraction 0.962607
Total Fragmentation 1635.0
Partition Asymmetry 0.445327
Average Rall's Ratio 1.97923
Average Bifurcation Angle Local 26.4385 °
Average Bifurcation Angle Remote 44.6386 °
Fractal Dimension 1.00986
Complexity Summary
State Equations 1680
Optimal Time-Step 0.00542 ms
Relative Complexity 605.02 HH
Model Size
Sections 121
Compartments 151
State Equations 1680
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00542 ms
Optimal Time-Step Error 0.45 %
Optimal Time-Step Benchmark Run Time 605.02 HH
 
Maximum Stable Time-Step 0.03125 ms
Maximum Stable Time-Step Error 1.75 %
Max. Stable Time-Step Benchmark Run Time 1639.34 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 32246 Hz
CVODE Steps Per AP 90
CVODE Benchmark Run Time 714.79 HH
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