Layer 5 Continuous Stuttering Nest Basket Cell (3)

Model Type:
Cell
Neurolex IDs: Neocortex basket cell
Neocortex Layer 5
Keywords: continuous stuttering,Layer 5,Fast-spiking, interneuron, GABAergic, inhibitory, neocortex, rat, somatosensory cortex, nest, basket, biophysical, continuous stuttering nest basket cell, Realistic Network, Neuron or other electrically excitable cell, Synapse, Spatio-temporal Activity Patterns, Detailed Neuronal Models
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000974
cSTUT189_L5_NBC_42f781cf08_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCH000115
StochKv_deterministic.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000974
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Fast Spikers (FS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -74.74 mV
Rheobase Current Interval (0.12474, 0.12589] nA
Threshold Current Interval (0.23438, 0.29297] nA
Bias Current (to -80.00 mV) -0.0230 nA
Testing Temperature 34.0 °C
Stability Interval [-0.9375, 15.0] nA
AP 1-2 Amplitude Drop 6.3571 mV
AP 1 Steady State Amplitude Change 7.7784 mV
AP 1 Amplitude 84.7545 mV
AP 1 Width at Half Height 0.5100 ms
AP 1 Width (Peak To Trough) 2.2000 ms
AP 1 Rate of Change Peak to Trough -49.1696 mV/ms
AP 1 AHP Depth 23.4185 mV
AP2 Amplitude 78.3974 mV
AP2 Width at Half Height 0.4700 ms
AP 2 Width (Peak to Trough) 2.1400 ms
AP 2 Rate of Change Peak to Trough -48.6072 mV/ms
AP 2 AHP Depth 25.6219 mV
AP 1-2 Amplitude Change Percent -7.5006 %
AP 1-2 Half Width Change Percent -7.8431 %
AP 1-2 Rate of Change Peak to Trough Percent Change -1.1438 %
AP 1-2 AHP Depth Percent Change 9.4087 %
Input Resistance 256.7953 MΩ
AP 1 Delay Mean 5.0800 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 26.8000 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 22.3750 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -11.1111 %
Steady State Accommodation Mean -11.1111 %
Accommodation Rate to Steady State -0.0128 %/ms
Accommodation at Steady State Mean -20.7140 %
Accommodation Rate Mean at Steady State 2387.4002 ms
ISI CV 24.8394
ISI Median 24.4650 ms
ISI Burst Mean Change 6.0313 %
Spike Rate (Strong Stimulation) 72.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 1.9400 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 13.1800 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 12.3950 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2119.7300 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 45.0335 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 12504.6 µm2
Number of Stems 8.0
Number of Bifurcations 29.0
Number of Branches 65.0
Overall Width 394.198 µm
Overall Height 556.317 µm
Overall Depth 171.97 µm
Average Diameter 0.69516 µm
Total Length 4418.47 µm
Total Surface 7567.92 µm2
Total Volume 4780.99 µm3
Max Euclidean Distance 507.555 µm
Max Path Distance 577.619 µm
Max Branch Order 7.0
Average Contraction 0.937038
Total Fragmentation 1603.0
Partition Asymmetry 0.562069
Average Rall's Ratio 0.698235
Average Bifurcation Angle Local 62.8757 °
Average Bifurcation Angle Remote 66.6887 °
Fractal Dimension 1.0096
Complexity Summary
Relative Complexity 708.63 HH
State Equations 2417
Optimal Time-Step 0.00537 ms
Model Size
Sections 66
Compartments 218
State Equations 2417
Variable Time-Step Complexity
CVODE Steady State Step Frequency 19520 Hz
CVODE Steps Per AP 315
CVODE Benchmark Run Time 708.63 HH
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