Layer 5 Continuous Stuttering Martinotti Cell (4)

Model Type:
Cell
Neurolex IDs: Martinotti Cell
Neocortex Layer 5
Keywords: continuous stuttering,Layer 5,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, Martinotti
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000970
cSTUT189_L5_MC_bf2b2fbcbf_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCH000115
StochKv_deterministic.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000970
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Fast Spikers (FS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -75.23 mV
Rheobase Current Interval (0.19707, 0.19867] nA
Threshold Current Interval (0.35156, 0.41016] nA
Bias Current (to -70.00 mV) 0.0485 nA
Testing Temperature 34.0 °C
Stability Interval [-1.25, 15.0] nA
AP 1-2 Amplitude Drop 6.7264 mV
AP 1 Steady State Amplitude Change 6.9625 mV
AP 1 Amplitude 76.8435 mV
AP 1 Width at Half Height 0.6000 ms
AP 1 Width (Peak To Trough) 2.4900 ms
AP 1 Rate of Change Peak to Trough -36.2151 mV/ms
AP 1 AHP Depth 13.3321 mV
AP2 Amplitude 70.1171 mV
AP2 Width at Half Height 0.6200 ms
AP 2 Width (Peak to Trough) 2.6200 ms
AP 2 Rate of Change Peak to Trough -32.1170 mV/ms
AP 2 AHP Depth 14.0295 mV
AP 1-2 Amplitude Change Percent -8.7534 %
AP 1-2 Half Width Change Percent 3.3333 %
AP 1-2 Rate of Change Peak to Trough Percent Change -11.3159 %
AP 1-2 AHP Depth Percent Change 5.2315 %
Input Resistance 129.5117 MΩ
AP 1 Delay Mean 4.9800 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 20.7900 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 17.3000 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean 0.0000 %
Steady State Accommodation Mean 4.5455 %
Accommodation Rate to Steady State 0.1148 %/ms
Accommodation at Steady State Mean -11.0848 %
Accommodation Rate Mean at Steady State 0.4884 ms
ISI CV 46.9440
ISI Median 17.6400 ms
ISI Burst Mean Change 18.8488 %
Spike Rate (Strong Stimulation) 108.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 1.5700 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 9.7000 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 8.7950 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2066.4900 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 60.7400 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 6045.57 µm2
Number of Stems 4.0
Number of Bifurcations 78.0
Number of Branches 159.0
Overall Width 364.656 µm
Overall Height 872.214 µm
Overall Depth 221.5 µm
Average Diameter 0.738131 µm
Total Length 6823.54 µm
Total Surface 15206.4 µm2
Total Volume 5426.1 µm3
Max Euclidean Distance 521.589 µm
Max Path Distance 600.306 µm
Max Branch Order 11.0
Average Contraction 0.937276
Total Fragmentation 8365.0
Partition Asymmetry 0.588923
Average Rall's Ratio 0.839914
Average Bifurcation Angle Local 27.5578 °
Average Bifurcation Angle Remote 72.0762 °
Fractal Dimension 1.01445
Complexity Summary
State Equations 4100
Optimal Time-Step 0.00757 ms
Relative Complexity 1132.16 HH
Model Size
Sections 159
Compartments 371
State Equations 4100
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00757 ms
Optimal Time-Step Error 0.68 %
Optimal Time-Step Benchmark Run Time 1132.16 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 3.28 %
Max. Stable Time-Step Benchmark Run Time 2143.30 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 19873 Hz
CVODE Steps Per AP 227
CVODE Benchmark Run Time 1248.77 HH
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