Layer 5 Continuous Stuttering Large Basket Cell (5)

Model Type:
Cell
Neurolex IDs: Neocortex basket cell
Neocortex Layer 5
Keywords: continuous stuttering,Layer 5,Fast-spiking, interneuron, GABAergic, inhibitory, neocortex, rat, somatosensory cortex, large, basket
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000966
cSTUT189_L5_LBC_7e5297a36c_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCH000115
StochKv_deterministic.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000966
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Fast Spikers (FS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -73.24 mV
Rheobase Current Interval (0.07965, 0.08034] nA
Threshold Current Interval (0.11719, 0.17578] nA
Bias Current (to -80.00 mV) -0.0201 nA
Testing Temperature 34.0 °C
Stability Interval [-0.625, 15.0] nA
AP 1-2 Amplitude Drop 5.8331 mV
AP 1 Steady State Amplitude Change 6.7800 mV
AP 1 Amplitude 87.3999 mV
AP 1 Width at Half Height 0.4500 ms
AP 1 Width (Peak To Trough) 2.2300 ms
AP 1 Rate of Change Peak to Trough -51.2074 mV/ms
AP 1 AHP Depth 26.7926 mV
AP2 Amplitude 81.5668 mV
AP2 Width at Half Height 0.4300 ms
AP 2 Width (Peak to Trough) 2.2100 ms
AP 2 Rate of Change Peak to Trough -49.7611 mV/ms
AP 2 AHP Depth 28.4053 mV
AP 1-2 Amplitude Change Percent -6.6740 %
AP 1-2 Half Width Change Percent -4.4444 %
AP 1-2 Rate of Change Peak to Trough Percent Change -2.8243 %
AP 1-2 AHP Depth Percent Change 6.0194 %
Input Resistance 407.9087 MΩ
AP 1 Delay Mean 5.0200 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 30.9700 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 26.3200 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -20.0000 %
Steady State Accommodation Mean -33.3333 %
Accommodation Rate to Steady State -0.0342 %/ms
Accommodation at Steady State Mean -36.4433 %
Accommodation Rate Mean at Steady State 855.6570 ms
ISI CV 8.6972
ISI Median 34.7900 ms
ISI Burst Mean Change 2.8516 %
Spike Rate (Strong Stimulation) 56.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 2.1600 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 15.8900 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 14.7100 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2233.1500 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 68.7404 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 15563.3 µm2
Number of Stems 9.0
Number of Bifurcations 6.0
Number of Branches 20.0
Overall Width 175.925 µm
Overall Height 222.18 µm
Overall Depth 55.35 µm
Average Diameter 0.782974 µm
Total Length 1255.89 µm
Total Surface 3126.68 µm2
Total Volume 4329.02 µm3
Max Euclidean Distance 175.193 µm
Max Path Distance 222.971 µm
Max Branch Order 2.0
Average Contraction 0.926104
Total Fragmentation 1036.0
Partition Asymmetry 0.333333
Average Rall's Ratio 0.707
Average Bifurcation Angle Local 0.0 °
Average Bifurcation Angle Remote 51.7157 °
Fractal Dimension 1.01532
Complexity Summary
State Equations 668
Optimal Time-Step 0.00780 ms
Relative Complexity 161.23 HH
Model Size
Sections 21
Compartments 59
State Equations 668
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00780 ms
Optimal Time-Step Error 0.27 %
Optimal Time-Step Benchmark Run Time 161.23 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 1.56 %
Max. Stable Time-Step Benchmark Run Time 314.19 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 17927 Hz
CVODE Steps Per AP 425
CVODE Benchmark Run Time 183.28 HH
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