Layer 5 Continuous Stuttering Large Basket Cell (3)

Model Type:
Cell
Neurolex IDs: Neocortex basket cell
Neocortex Layer 5
Keywords: continuous stuttering,Layer 5,Fast-spiking, interneuron, GABAergic, inhibitory, neocortex, rat, somatosensory cortex, large, basket
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000964
cSTUT189_L5_LBC_640a1cef1d_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCH000115
StochKv_deterministic.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000964
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Fast Spikers (FS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -75.11 mV
Rheobase Current Interval (0.12817, 0.12932] nA
Threshold Current Interval (0.23438, 0.29297] nA
Bias Current (to -70.00 mV) 0.0278 nA
Testing Temperature 34.0 °C
Stability Interval [-0.9375, 15.0] nA
AP 1-2 Amplitude Drop 3.4743 mV
AP 1 Steady State Amplitude Change 4.2866 mV
AP 1 Amplitude 82.1308 mV
AP 1 Width at Half Height 0.5300 ms
AP 1 Width (Peak To Trough) 2.6900 ms
AP 1 Rate of Change Peak to Trough -38.1397 mV/ms
AP 1 AHP Depth 20.4651 mV
AP2 Amplitude 78.6565 mV
AP2 Width at Half Height 0.5100 ms
AP 2 Width (Peak to Trough) 2.7400 ms
AP 2 Rate of Change Peak to Trough -36.4146 mV/ms
AP 2 AHP Depth 21.1194 mV
AP 1-2 Amplitude Change Percent -4.2302 %
AP 1-2 Half Width Change Percent -3.7736 %
AP 1-2 Rate of Change Peak to Trough Percent Change -4.5233 %
AP 1-2 AHP Depth Percent Change 3.1972 %
Input Resistance 268.5988 MΩ
AP 1 Delay Mean 5.6300 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 26.2800 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 21.4600 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -5.5556 %
Steady State Accommodation Mean -11.1111 %
Accommodation Rate to Steady State -0.0133 %/ms
Accommodation at Steady State Mean -21.8440 %
Accommodation Rate Mean at Steady State 3228.3039 ms
ISI CV 28.1099
ISI Median 23.3300 ms
ISI Burst Mean Change 7.8450 %
Spike Rate (Strong Stimulation) 75.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 2.1900 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 13.2000 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 12.1000 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2122.2600 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 73.7818 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 11579.5 µm2
Number of Stems 8.0
Number of Bifurcations 48.0
Number of Branches 103.0
Overall Width 288.43 µm
Overall Height 416.679 µm
Overall Depth 359.27 µm
Average Diameter 0.661827 µm
Total Length 4888.8 µm
Total Surface 6367.99 µm2
Total Volume 4253.29 µm3
Max Euclidean Distance 306.027 µm
Max Path Distance 350.428 µm
Max Branch Order 10.0
Average Contraction 0.97544
Total Fragmentation 2271.0
Partition Asymmetry 0.455871
Average Rall's Ratio 0.5002
Average Bifurcation Angle Local 22.3206 °
Average Bifurcation Angle Remote 43.4187 °
Fractal Dimension 1.00497
Complexity Summary
State Equations 2813
Optimal Time-Step 0.00545 ms
Relative Complexity 1029.05 HH
Model Size
Sections 104
Compartments 254
State Equations 2813
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00545 ms
Optimal Time-Step Error 0.29 %
Optimal Time-Step Benchmark Run Time 1029.05 HH
 
Maximum Stable Time-Step 0.03125 ms
Maximum Stable Time-Step Error 1.23 %
Max. Stable Time-Step Benchmark Run Time 2805.63 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 19944 Hz
CVODE Steps Per AP 303
CVODE Benchmark Run Time 847.78 HH
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