Layer 4 Continuous Stuttering Neurogliaform Cell (2)

Model Type:
Cell
Neurolex IDs: Neocortex Layer 4
Keywords: continuous stuttering,Layer 4,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, neurogliaform
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000958
cSTUT189_L4_NGC_1c20d72451_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCH000115
StochKv_deterministic.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000958
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Fast Spikers (FS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -76.36 mV
Rheobase Current Interval (0.18951, 0.19157] nA
Threshold Current Interval (0.46875, 0.52734] nA
Bias Current (to -70.00 mV) 0.0453 nA
Testing Temperature 34.0 °C
Stability Interval [-1.5625, 15.0] nA
AP 1-2 Amplitude Drop 5.5806 mV
AP 1 Steady State Amplitude Change 5.9327 mV
AP 1 Amplitude 66.3983 mV
AP 1 Width at Half Height 0.8400 ms
AP 1 Width (Peak To Trough) 4.8600 ms
AP 1 Rate of Change Peak to Trough -16.0374 mV/ms
AP 1 AHP Depth 11.5436 mV
AP2 Amplitude 60.8176 mV
AP2 Width at Half Height 0.8800 ms
AP 2 Width (Peak to Trough) 5.3700 ms
AP 2 Rate of Change Peak to Trough -13.5961 mV/ms
AP 2 AHP Depth 12.1936 mV
AP 1-2 Amplitude Change Percent -8.4048 %
AP 1-2 Half Width Change Percent 4.7619 %
AP 1-2 Rate of Change Peak to Trough Percent Change -15.2224 %
AP 1-2 AHP Depth Percent Change 5.6312 %
Input Resistance 185.8960 MΩ
AP 1 Delay Mean 7.1200 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 25.7200 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 19.4600 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean 5.0000 %
Steady State Accommodation Mean 5.0000 %
Accommodation Rate to Steady State 0.1944 %/ms
Accommodation at Steady State Mean -4.6004 %
Accommodation Rate Mean at Steady State 0.1359 ms
ISI CV 73.1642
ISI Median 19.3950 ms
ISI Burst Mean Change 9.2473 %
Spike Rate (Strong Stimulation) 99.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 2.8400 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 12.1300 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 10.0800 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2093.9400 ms
Frequency Filter Type Constant
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 5040.39 µm2
Number of Stems 6.0
Number of Bifurcations 57.0
Number of Branches 119.0
Overall Width 226.009 µm
Overall Height 237.933 µm
Overall Depth 260.96 µm
Average Diameter 0.686537 µm
Total Length 5628.58 µm
Total Surface 9743.42 µm2
Total Volume 2875.72 µm3
Max Euclidean Distance 212.205 µm
Max Path Distance 292.37 µm
Max Branch Order 6.0
Average Contraction 0.968608
Total Fragmentation 1382.0
Partition Asymmetry 0.314716
Average Rall's Ratio 1.42675
Average Bifurcation Angle Local 41.1419 °
Average Bifurcation Angle Remote 58.9674 °
Fractal Dimension 1.00501
Complexity Summary
State Equations 3187
Optimal Time-Step 0.00773 ms
Relative Complexity 805.87 HH
Model Size
Sections 120
Compartments 288
State Equations 3187
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00773 ms
Optimal Time-Step Error 0.40 %
Optimal Time-Step Benchmark Run Time 805.87 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 2.41 %
Max. Stable Time-Step Benchmark Run Time 1556.59 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 16530 Hz
CVODE Steps Per AP 241
CVODE Benchmark Run Time 775.58 HH
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