Layer 4 Continuous Stuttering Large Basket Cell (4)

Model Type:
Cell
Neurolex IDs: Neocortex basket cell
Neocortex Layer 4
Keywords: continuous stuttering,Layer 4,Fast-spiking, interneuron, GABAergic, inhibitory, neocortex, rat, somatosensory cortex, large, basket
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000955
cSTUT189_L4_LBC_2a3578f975_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCH000115
StochKv_deterministic.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000955
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Fast Spikers (FS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -75.78 mV
Rheobase Current Interval (0.13458, 0.13596] nA
Threshold Current Interval (0.29297, 0.35156] nA
Bias Current (to -70.00 mV) 0.0332 nA
Testing Temperature 34.0 °C
Stability Interval [-0.9375, 15.0] nA
AP 1-2 Amplitude Drop 4.1256 mV
AP 1 Steady State Amplitude Change 4.1211 mV
AP 1 Amplitude 76.2990 mV
AP 1 Width at Half Height 0.6100 ms
AP 1 Width (Peak To Trough) 2.8700 ms
AP 1 Rate of Change Peak to Trough -31.9882 mV/ms
AP 1 AHP Depth 15.5071 mV
AP2 Amplitude 72.1734 mV
AP2 Width at Half Height 0.6100 ms
AP 2 Width (Peak to Trough) 3.0300 ms
AP 2 Rate of Change Peak to Trough -29.3874 mV/ms
AP 2 AHP Depth 16.8703 mV
AP 1-2 Amplitude Change Percent -5.4071 %
AP 1-2 Half Width Change Percent 0.0000 %
AP 1-2 Rate of Change Peak to Trough Percent Change -8.1305 %
AP 1-2 AHP Depth Percent Change 8.7910 %
Input Resistance 228.1321 MΩ
AP 1 Delay Mean 6.3000 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 24.6100 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 19.3650 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean 5.0000 %
Steady State Accommodation Mean 0.0000 %
Accommodation Rate to Steady State 0.0000 %/ms
Accommodation at Steady State Mean -8.1056 %
Accommodation Rate Mean at Steady State 0.1797 ms
ISI CV 85.5762
ISI Median 19.8950 ms
ISI Burst Mean Change 11.5238 %
Spike Rate (Strong Stimulation) 93.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 2.2100 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 11.3100 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 10.0700 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2093.5800 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 45.0485 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 4975.86 µm2
Number of Stems 4.0
Number of Bifurcations 25.0
Number of Branches 53.0
Overall Width 339.52 µm
Overall Height 698.918 µm
Overall Depth 162.49 µm
Average Diameter 0.926096 µm
Total Length 3000.11 µm
Total Surface 7893.36 µm2
Total Volume 3704.36 µm3
Max Euclidean Distance 460.333 µm
Max Path Distance 554.246 µm
Max Branch Order 11.0
Average Contraction 0.939131
Total Fragmentation 2119.0
Partition Asymmetry 0.636061
Average Rall's Ratio 0.926579
Average Bifurcation Angle Local 7.57381 °
Average Bifurcation Angle Remote 75.1071 °
Fractal Dimension 1.01104
Complexity Summary
State Equations 1735
Optimal Time-Step 0.00540 ms
Relative Complexity 610.65 HH
Model Size
Sections 54
Compartments 156
State Equations 1735
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00540 ms
Optimal Time-Step Error 0.26 %
Optimal Time-Step Benchmark Run Time 610.65 HH
 
Maximum Stable Time-Step 0.03125 ms
Maximum Stable Time-Step Error 1.09 %
Max. Stable Time-Step Benchmark Run Time 1646.75 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 18480 Hz
CVODE Steps Per AP 301
CVODE Benchmark Run Time 465.59 HH
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