Layer 2/3 Continuous Stuttering Large Basket Cell (5)

Model Type:
Cell
Neurolex IDs: Neocortex basket cell
Neocortex Layer 2
Neocortex Layer 3
Keywords: continuous stuttering,Layer 2, Layer 3, Layer 2/3,Fast-spiking, interneuron, GABAergic, inhibitory, neocortex, rat, somatosensory cortex, large, basket, biophysical, continuous stuttering large basket cell, Realistic Network, Neuron or other electrically excitable cell, Synapse, Spatio-temporal Activity Patterns, Detailed Neuronal Models
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000946
cSTUT189_L23_LBC_e6e8f83407_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCH000115
StochKv_deterministic.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000946
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Fast Spikers (FS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -75.29 mV
Rheobase Current Interval (0.15541, 0.15701] nA
Threshold Current Interval (0.35156, 0.41016] nA
Bias Current (to -70.00 mV) 0.0330 nA
Testing Temperature 34.0 °C
Stability Interval [-1.25, 15.0] nA
AP 1-2 Amplitude Drop 4.9001 mV
AP 1 Steady State Amplitude Change 5.3448 mV
AP 1 Amplitude 77.2019 mV
AP 1 Width at Half Height 0.5900 ms
AP 1 Width (Peak To Trough) 2.8900 ms
AP 1 Rate of Change Peak to Trough -33.2344 mV/ms
AP 1 AHP Depth 18.8456 mV
AP2 Amplitude 72.3017 mV
AP2 Width at Half Height 0.6100 ms
AP 2 Width (Peak to Trough) 2.9500 ms
AP 2 Rate of Change Peak to Trough -31.0562 mV/ms
AP 2 AHP Depth 19.3140 mV
AP 1-2 Amplitude Change Percent -6.3472 %
AP 1-2 Half Width Change Percent 3.3898 %
AP 1-2 Rate of Change Peak to Trough Percent Change -6.5542 %
AP 1-2 AHP Depth Percent Change 2.4854 %
Input Resistance 219.3554 MΩ
AP 1 Delay Mean 6.0200 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 25.7700 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 20.6300 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -5.2632 %
Steady State Accommodation Mean -5.2632 %
Accommodation Rate to Steady State -0.1113 %/ms
Accommodation at Steady State Mean -8.8246 %
Accommodation Rate Mean at Steady State 9.1076 ms
ISI CV 53.6888
ISI Median 21.6150 ms
ISI Burst Mean Change 8.9114 %
Spike Rate (Strong Stimulation) 82.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 2.3300 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 12.4700 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 11.1900 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2111.3700 ms
Frequency Filter Type Constant
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 8236.63 µm2
Number of Stems 6.0
Number of Bifurcations 20.0
Number of Branches 45.0
Overall Width 262.964 µm
Overall Height 462.792 µm
Overall Depth 144.56 µm
Average Diameter 0.792958 µm
Total Length 3376.32 µm
Total Surface 7753.81 µm2
Total Volume 3931.64 µm3
Max Euclidean Distance 467.445 µm
Max Path Distance 503.677 µm
Max Branch Order 5.0
Average Contraction 0.954585
Total Fragmentation 1287.0
Partition Asymmetry 0.385
Average Rall's Ratio 1.11147
Average Bifurcation Angle Local 48.508 °
Average Bifurcation Angle Remote 64.0402 °
Fractal Dimension 1.00652
Complexity Summary
Relative Complexity 463.74 HH
State Equations 1845
Optimal Time-Step 0.00776 ms
Model Size
Sections 46
Compartments 166
State Equations 1845
Variable Time-Step Complexity
CVODE Steady State Step Frequency 17124 Hz
CVODE Steps Per AP 236
CVODE Benchmark Run Time 463.74 HH
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