Layer 2/3 Continuous Stuttering Large Basket Cell (4)

Model Type:
Cell
Neurolex IDs: Neocortex basket cell
Neocortex Layer 2
Neocortex Layer 3
Keywords: continuous stuttering,Layer 2, Layer 3, Layer 2/3,Fast-spiking, interneuron, GABAergic, inhibitory, neocortex, rat, somatosensory cortex, large, basket
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000945
cSTUT189_L23_LBC_d2eb341534_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCH000115
StochKv_deterministic.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000945
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Fast Spikers (FS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -75.53 mV
Rheobase Current Interval (0.12772, 0.12909] nA
Threshold Current Interval (0.29297, 0.35156] nA
Bias Current (to -70.00 mV) 0.0299 nA
Testing Temperature 34.0 °C
Stability Interval [-0.9375, 15.0] nA
AP 1-2 Amplitude Drop 3.8863 mV
AP 1 Steady State Amplitude Change 4.2177 mV
AP 1 Amplitude 75.8477 mV
AP 1 Width at Half Height 0.6300 ms
AP 1 Width (Peak To Trough) 3.1500 ms
AP 1 Rate of Change Peak to Trough -29.3800 mV/ms
AP 1 AHP Depth 16.6993 mV
AP2 Amplitude 71.9614 mV
AP2 Width at Half Height 0.6400 ms
AP 2 Width (Peak to Trough) 3.3200 ms
AP 2 Rate of Change Peak to Trough -26.8879 mV/ms
AP 2 AHP Depth 17.3064 mV
AP 1-2 Amplitude Change Percent -5.1238 %
AP 1-2 Half Width Change Percent 1.5873 %
AP 1-2 Rate of Change Peak to Trough Percent Change -8.4823 %
AP 1-2 AHP Depth Percent Change 3.6354 %
Input Resistance 249.0904 MΩ
AP 1 Delay Mean 6.7000 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 26.2800 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 20.4400 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean 0.0000 %
Steady State Accommodation Mean 0.0000 %
Accommodation Rate to Steady State 0.0000 %/ms
Accommodation at Steady State Mean -7.3002 %
Accommodation Rate Mean at Steady State 0.1446 ms
ISI CV 85.7570
ISI Median 21.1150 ms
ISI Burst Mean Change 8.7845 %
Spike Rate (Strong Stimulation) 85.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 2.4600 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 12.4400 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 10.9650 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2088.7400 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 32.5160 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 4363.56 µm2
Number of Stems 8.0
Number of Bifurcations 12.0
Number of Branches 31.0
Overall Width 395.856 µm
Overall Height 476.349 µm
Overall Depth 258.63 µm
Average Diameter 0.771216 µm
Total Length 3488.27 µm
Total Surface 7051.7 µm2
Total Volume 2356.31 µm3
Max Euclidean Distance 353.025 µm
Max Path Distance 465.923 µm
Max Branch Order 3.0
Average Contraction 0.95356
Total Fragmentation 943.0
Partition Asymmetry 0.433333
Average Rall's Ratio 0.854286
Average Bifurcation Angle Local 26.2096 °
Average Bifurcation Angle Remote 50.1349 °
Fractal Dimension 1.00887
Complexity Summary
State Equations 1867
Optimal Time-Step 0.00768 ms
Relative Complexity 474.15 HH
Model Size
Sections 32
Compartments 168
State Equations 1867
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00768 ms
Optimal Time-Step Error 0.29 %
Optimal Time-Step Benchmark Run Time 474.15 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 1.46 %
Max. Stable Time-Step Benchmark Run Time 909.88 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 16925 Hz
CVODE Steps Per AP 278
CVODE Benchmark Run Time 471.66 HH
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