Layer 2/3 Continuous Stuttering Large Basket Cell (2)

Model Type:
Cell
Neurolex IDs: Neocortex basket cell
Neocortex Layer 2
Neocortex Layer 3
Keywords: continuous stuttering,Layer 2, Layer 3, Layer 2/3,Fast-spiking, interneuron, GABAergic, inhibitory, neocortex, rat, somatosensory cortex, large, basket
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000943
cSTUT189_L23_LBC_222e20da8f_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCH000115
StochKv_deterministic.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000943
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Fast Spikers (FS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -75.26 mV
Rheobase Current Interval (0.09247, 0.09338] nA
Threshold Current Interval (0.17578, 0.23438] nA
Bias Current (to -70.00 mV) 0.0197 nA
Testing Temperature 34.0 °C
Stability Interval [-0.625, 15.0] nA
AP 1-2 Amplitude Drop 3.9671 mV
AP 1 Steady State Amplitude Change 5.1356 mV
AP 1 Amplitude 74.4573 mV
AP 1 Width at Half Height 0.6700 ms
AP 1 Width (Peak To Trough) 3.5600 ms
AP 1 Rate of Change Peak to Trough -26.4242 mV/ms
AP 1 AHP Depth 19.6127 mV
AP2 Amplitude 70.4902 mV
AP2 Width at Half Height 0.6900 ms
AP 2 Width (Peak to Trough) 3.6600 ms
AP 2 Rate of Change Peak to Trough -24.7091 mV/ms
AP 2 AHP Depth 19.9451 mV
AP 1-2 Amplitude Change Percent -5.3280 %
AP 1-2 Half Width Change Percent 2.9851 %
AP 1-2 Rate of Change Peak to Trough Percent Change -6.4905 %
AP 1-2 AHP Depth Percent Change 1.6948 %
Input Resistance 404.2223 MΩ
AP 1 Delay Mean 6.4200 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 26.7400 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 21.1450 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -5.5556 %
Steady State Accommodation Mean -11.1111 %
Accommodation Rate to Steady State -0.0120 %/ms
Accommodation at Steady State Mean -22.0719 %
Accommodation Rate Mean at Steady State 2216.8722 ms
ISI CV 22.0986
ISI Median 23.5200 ms
ISI Burst Mean Change 8.1201 %
Spike Rate (Strong Stimulation) 74.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 2.8600 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 14.0000 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 12.0950 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2139.2600 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 75.7915 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 4908.99 µm2
Number of Stems 5.0
Number of Bifurcations 22.0
Number of Branches 48.0
Overall Width 149.719 µm
Overall Height 293.148 µm
Overall Depth 110.76 µm
Average Diameter 0.943648 µm
Total Length 1937.33 µm
Total Surface 4367.07 µm2
Total Volume 2105.17 µm3
Max Euclidean Distance 216.235 µm
Max Path Distance 234.688 µm
Max Branch Order 4.0
Average Contraction 0.969234
Total Fragmentation 512.0
Partition Asymmetry 0.321212
Average Rall's Ratio 1.27133
Average Bifurcation Angle Local 46.6868 °
Average Bifurcation Angle Remote 56.7724 °
Fractal Dimension 1.00504
Complexity Summary
State Equations 1086
Optimal Time-Step 0.00779 ms
Relative Complexity 269.61 HH
Model Size
Sections 49
Compartments 97
State Equations 1086
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00779 ms
Optimal Time-Step Error 0.47 %
Optimal Time-Step Benchmark Run Time 269.61 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 2.33 %
Max. Stable Time-Step Benchmark Run Time 524.72 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 15147 Hz
CVODE Steps Per AP 322
CVODE Benchmark Run Time 253.55 HH
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