Layer 1 Continuous Stuttering Neurogliaform Cell with dense axonal arborization (5)

Model Type:
Cell
Neurolex IDs: Neocortex Layer 1
Keywords: continuous stuttering,Layer 1,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, neocortex, neurogliaform, dense axonal arborization
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000941
cSTUT189_L1_NGCDA_e1a52c74bf_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCH000115
StochKv_deterministic.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000941
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Fast Spikers (FS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -74.15 mV
Rheobase Current Interval (0.05905, 0.05974] nA
Threshold Current Interval (0.11719, 0.17578] nA
Bias Current (to -80.00 mV) -0.0118 nA
Testing Temperature 34.0 °C
Stability Interval [-0.3125, 15.0] nA
AP 1-2 Amplitude Drop 3.7356 mV
AP 1 Steady State Amplitude Change 4.7849 mV
AP 1 Amplitude 83.5310 mV
AP 1 Width at Half Height 0.5600 ms
AP 1 Width (Peak To Trough) 2.8200 ms
AP 1 Rate of Change Peak to Trough -38.2608 mV/ms
AP 1 AHP Depth 24.3643 mV
AP2 Amplitude 79.7955 mV
AP2 Width at Half Height 0.5600 ms
AP 2 Width (Peak to Trough) 2.8100 ms
AP 2 Rate of Change Peak to Trough -37.2577 mV/ms
AP 2 AHP Depth 24.8985 mV
AP 1-2 Amplitude Change Percent -4.4721 %
AP 1-2 Half Width Change Percent 0.0000 %
AP 1-2 Rate of Change Peak to Trough Percent Change -2.6217 %
AP 1-2 AHP Depth Percent Change 2.1928 %
Input Resistance 595.6652 MΩ
AP 1 Delay Mean 6.0400 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 28.8000 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 23.4050 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -17.6471 %
Steady State Accommodation Mean -23.5294 %
Accommodation Rate to Steady State -0.0241 %/ms
Accommodation at Steady State Mean -32.0792 %
Accommodation Rate Mean at Steady State 1014.3671 ms
ISI CV 10.4414
ISI Median 29.4250 ms
ISI Burst Mean Change 5.6678 %
Spike Rate (Strong Stimulation) 61.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 2.7100 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 15.2400 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 13.5350 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2153.2200 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 45.0335 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 5442.17 µm2
Number of Stems 4.0
Number of Bifurcations 18.0
Number of Branches 39.0
Overall Width 131.204 µm
Overall Height 87.3484 µm
Overall Depth 58.75 µm
Average Diameter 1.06234 µm
Total Length 894.253 µm
Total Surface 2617.17 µm2
Total Volume 1982.67 µm3
Max Euclidean Distance 103.737 µm
Max Path Distance 177.597 µm
Max Branch Order 6.0
Average Contraction 0.917451
Total Fragmentation 603.0
Partition Asymmetry 0.54321
Average Rall's Ratio 1.48
Average Bifurcation Angle Local 52.0891 °
Average Bifurcation Angle Remote 82.6378 °
Fractal Dimension 1.01699
Complexity Summary
State Equations 613
Optimal Time-Step 0.00542 ms
Relative Complexity 204.50 HH
Model Size
Sections 40
Compartments 54
State Equations 613
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00542 ms
Optimal Time-Step Error 0.21 %
Optimal Time-Step Benchmark Run Time 204.50 HH
 
Maximum Stable Time-Step 0.03125 ms
Maximum Stable Time-Step Error 0.78 %
Max. Stable Time-Step Benchmark Run Time 554.08 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 14898 Hz
CVODE Steps Per AP 369
CVODE Benchmark Run Time 135.45 HH
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