Layer 1 Continuous Stuttering Neurogliaform Cell with dense axonal arborization (1)

Model Type:
Cell
Neurolex IDs: Neocortex Layer 1
Keywords: continuous stuttering,Layer 1,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, neocortex, neurogliaform, dense axonal arborization
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000937
cSTUT189_L1_NGCDA_0112c85cf0_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCH000115
StochKv_deterministic.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000937
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Fast Spikers (FS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -74.50 mV
Rheobase Current Interval (0.07233, 0.07324] nA
Threshold Current Interval (0.17578, 0.23438] nA
Bias Current (to -80.00 mV) -0.0129 nA
Testing Temperature 34.0 °C
Stability Interval [-0.625, 15.0] nA
AP 1-2 Amplitude Drop 4.3036 mV
AP 1 Steady State Amplitude Change 5.7135 mV
AP 1 Amplitude 78.5595 mV
AP 1 Width at Half Height 0.5900 ms
AP 1 Width (Peak To Trough) 3.0900 ms
AP 1 Rate of Change Peak to Trough -33.4887 mV/ms
AP 1 AHP Depth 24.9206 mV
AP2 Amplitude 74.2559 mV
AP2 Width at Half Height 0.6000 ms
AP 2 Width (Peak to Trough) 3.1000 ms
AP 2 Rate of Change Peak to Trough -32.1859 mV/ms
AP 2 AHP Depth 25.5202 mV
AP 1-2 Amplitude Change Percent -5.4781 %
AP 1-2 Half Width Change Percent 1.6949 %
AP 1-2 Rate of Change Peak to Trough Percent Change -3.8904 %
AP 1-2 AHP Depth Percent Change 2.4061 %
Input Resistance 499.7555 MΩ
AP 1 Delay Mean 6.5600 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 28.6500 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 22.7800 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -17.6471 %
Steady State Accommodation Mean -17.6471 %
Accommodation Rate to Steady State -0.0175 %/ms
Accommodation at Steady State Mean -27.8007 %
Accommodation Rate Mean at Steady State 1232.1719 ms
ISI CV 13.1074
ISI Median 27.1750 ms
ISI Burst Mean Change 6.2472 %
Spike Rate (Strong Stimulation) 65.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 2.8500 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 15.0200 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 13.0950 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2128.6900 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 45.0335 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 5750.6 µm2
Number of Stems 6.0
Number of Bifurcations 18.0
Number of Branches 41.0
Overall Width 165.567 µm
Overall Height 156.942 µm
Overall Depth 88.09 µm
Average Diameter 1.00853 µm
Total Length 1233.96 µm
Total Surface 3455.46 µm2
Total Volume 2272.58 µm3
Max Euclidean Distance 142.35 µm
Max Path Distance 188.567 µm
Max Branch Order 5.0
Average Contraction 0.942844
Total Fragmentation 745.0
Partition Asymmetry 0.527778
Average Rall's Ratio 1.94409
Average Bifurcation Angle Local 51.3044 °
Average Bifurcation Angle Remote 58.0684 °
Fractal Dimension 1.01383
Complexity Summary
State Equations 723
Optimal Time-Step 0.00782 ms
Relative Complexity 172.77 HH
Model Size
Sections 42
Compartments 64
State Equations 723
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00782 ms
Optimal Time-Step Error 0.25 %
Optimal Time-Step Benchmark Run Time 172.77 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 1.80 %
Max. Stable Time-Step Benchmark Run Time 337.60 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 14221 Hz
CVODE Steps Per AP 325
CVODE Benchmark Run Time 155.19 HH
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