Layer 6 Continuous Non-accommodating Neurogliaform Cell (5)

Model Type:
Cell
Neurolex IDs: Neocortex Layer 6
Keywords: continuous non-accommodating,Layer 6,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, neurogliaform, biophysical, continuous non-accommodating neurogliaform cell, Realistic Network, Neuron or other electrically excitable cell, Synapse, Spatio-temporal Activity Patterns, Detailed Neuronal Models
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000936
cNAC187_L6_NGC_f566e0b2a9_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000936
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Non-accommodating Regular Spikers (naRS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -69.07 mV
Rheobase Current Interval (0.01579, 0.01648] nA
Threshold Current Interval (0.11719, 0.17578] nA
Bias Current (to -80.00 mV) -0.0148 nA
Testing Temperature 34.0 °C
Stability Interval [-1.5625, 15.0] nA
AP 1-2 Amplitude Drop -0.2914 mV
AP 1 Steady State Amplitude Change 0.9914 mV
AP 1 Amplitude 59.6685 mV
AP 1 Width at Half Height 0.8900 ms
AP 1 Width (Peak To Trough) 8.6100 ms
AP 1 Rate of Change Peak to Trough -9.2548 mV/ms
AP 1 AHP Depth 20.0155 mV
AP2 Amplitude 59.9599 mV
AP2 Width at Half Height 0.8900 ms
AP 2 Width (Peak to Trough) 8.4800 ms
AP 2 Rate of Change Peak to Trough -9.4088 mV/ms
AP 2 AHP Depth 19.8267 mV
AP 1-2 Amplitude Change Percent 0.4883 %
AP 1-2 Half Width Change Percent 0.0000 %
AP 1-2 Rate of Change Peak to Trough Percent Change 1.6638 %
AP 1-2 AHP Depth Percent Change -0.9432 %
Input Resistance 749.1166 MΩ
AP 1 Delay Mean 40.3500 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 109.3500 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 69.2350 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean 0.0000 %
Steady State Accommodation Mean -16.6667 %
Accommodation Rate to Steady State -0.0223 %/ms
Accommodation at Steady State Mean -13.5786 %
Accommodation Rate Mean at Steady State 1582.4689 ms
ISI CV 32.9232
ISI Median 73.5550 ms
ISI Burst Mean Change 0.6812 %
Spike Rate (Strong Stimulation) 26.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 16.5400 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 52.6500 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 36.6300 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2098.9700 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 53.6637 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 3387.44 µm2
Number of Stems 6.0
Number of Bifurcations 58.0
Number of Branches 121.0
Overall Width 123.368 µm
Overall Height 150.734 µm
Overall Depth 101.84 µm
Average Diameter 0.716829 µm
Total Length 2450.98 µm
Total Surface 5240.25 µm2
Total Volume 1731.78 µm3
Max Euclidean Distance 132.411 µm
Max Path Distance 166.569 µm
Max Branch Order 8.0
Average Contraction 0.962193
Total Fragmentation 1635.0
Partition Asymmetry 0.445327
Average Rall's Ratio 1.97923
Average Bifurcation Angle Local 25.3797 °
Average Bifurcation Angle Remote 44.9103 °
Fractal Dimension 1.00989
Complexity Summary
Relative Complexity 418.56 HH
State Equations 1491
Optimal Time-Step 0.00535 ms
Model Size
Sections 121
Compartments 147
State Equations 1491
Variable Time-Step Complexity
CVODE Steady State Step Frequency 20917 Hz
CVODE Steps Per AP 346
CVODE Benchmark Run Time 418.56 HH
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