Layer 6 Continuous Non-accommodating Neurogliaform Cell (1)

Model Type:
Cell
Neurolex IDs: Neocortex Layer 6
Keywords: continuous non-accommodating,Layer 6,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, neurogliaform
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000932
cNAC187_L6_NGC_43bfe487c7_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000932
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Non-accommodating Regular Spikers (naRS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -69.06 mV
Rheobase Current Interval (0.01648, 0.01740] nA
Threshold Current Interval (0.17578, 0.23438] nA
Bias Current (to -80.00 mV) -0.0149 nA
Testing Temperature 34.0 °C
Stability Interval [-0.9375, 15.0] nA
AP 1-2 Amplitude Drop -0.1656 mV
AP 1 Steady State Amplitude Change 0.2736 mV
AP 1 Amplitude 59.4528 mV
AP 1 Width at Half Height 0.8900 ms
AP 1 Width (Peak To Trough) 8.5900 ms
AP 1 Rate of Change Peak to Trough -9.2454 mV/ms
AP 1 AHP Depth 19.9656 mV
AP2 Amplitude 59.6184 mV
AP2 Width at Half Height 0.8900 ms
AP 2 Width (Peak to Trough) 8.4200 ms
AP 2 Rate of Change Peak to Trough -9.4463 mV/ms
AP 2 AHP Depth 19.9199 mV
AP 1-2 Amplitude Change Percent 0.2785 %
AP 1-2 Half Width Change Percent 0.0000 %
AP 1-2 Rate of Change Peak to Trough Percent Change 2.1730 %
AP 1-2 AHP Depth Percent Change -0.2290 %
Input Resistance 742.7451 MΩ
AP 1 Delay Mean 37.7900 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 103.3300 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 65.7550 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean 0.0000 %
Steady State Accommodation Mean 0.0000 %
Accommodation Rate to Steady State 0.0000 %/ms
Accommodation at Steady State Mean -12.6954 %
Accommodation Rate Mean at Steady State 1614.7681 ms
ISI CV 35.5154
ISI Median 69.5700 ms
ISI Burst Mean Change 0.6561 %
Spike Rate (Strong Stimulation) 27.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 15.8300 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 50.6400 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 35.2950 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2098.5000 ms
Frequency Filter Type Constant
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 3387.44 µm2
Number of Stems 6.0
Number of Bifurcations 58.0
Number of Branches 121.0
Overall Width 222.319 µm
Overall Height 125.557 µm
Overall Depth 96.86 µm
Average Diameter 0.716855 µm
Total Length 2476.83 µm
Total Surface 5308.39 µm2
Total Volume 1746.33 µm3
Max Euclidean Distance 150.441 µm
Max Path Distance 184.757 µm
Max Branch Order 8.0
Average Contraction 0.963034
Total Fragmentation 1635.0
Partition Asymmetry 0.445327
Average Rall's Ratio 1.97923
Average Bifurcation Angle Local 29.7176 °
Average Bifurcation Angle Remote 44.8678 °
Fractal Dimension 1.00977
Complexity Summary
State Equations 1531
Optimal Time-Step 0.00544 ms
Relative Complexity 509.26 HH
Model Size
Sections 121
Compartments 151
State Equations 1531
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00544 ms
Optimal Time-Step Error 0.18 %
Optimal Time-Step Benchmark Run Time 509.26 HH
 
Maximum Stable Time-Step 0.03125 ms
Maximum Stable Time-Step Error 0.83 %
Max. Stable Time-Step Benchmark Run Time 1384.07 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 21061 Hz
CVODE Steps Per AP 326
CVODE Benchmark Run Time 442.78 HH
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