Layer 6 Continuous Non-accommodating Nest Basket Cell (5)

Model Type:
Cell
Neurolex IDs: Neocortex basket cell
Neocortex Layer 6
Keywords: continuous non-accommodating,Layer 6,Fast-spiking, interneuron, GABAergic, inhibitory, neocortex, rat, somatosensory cortex, nest, basket
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000931
cNAC187_L6_NBC_c0fd8f67e2_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000931
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Non-accommodating Regular Spikers (naRS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -69.15 mV
Rheobase Current Interval (0.04807, 0.04944] nA
Threshold Current Interval (0.29297, 0.35156] nA
Bias Current (to -80.00 mV) -0.0380 nA
Testing Temperature 34.0 °C
Stability Interval [-2.8125, 15.0] nA
AP 1-2 Amplitude Drop -0.1338 mV
AP 1 Steady State Amplitude Change 0.4840 mV
AP 1 Amplitude 71.4081 mV
AP 1 Width at Half Height 0.6000 ms
AP 1 Width (Peak To Trough) 3.8900 ms
AP 1 Rate of Change Peak to Trough -24.2404 mV/ms
AP 1 AHP Depth 22.8871 mV
AP2 Amplitude 71.5418 mV
AP2 Width at Half Height 0.5900 ms
AP 2 Width (Peak to Trough) 4.0100 ms
AP 2 Rate of Change Peak to Trough -23.4914 mV/ms
AP 2 AHP Depth 22.6586 mV
AP 1-2 Amplitude Change Percent 0.1873 %
AP 1-2 Half Width Change Percent -1.6667 %
AP 1-2 Rate of Change Peak to Trough Percent Change -3.0900 %
AP 1-2 AHP Depth Percent Change -0.9983 %
Input Resistance 285.3590 MΩ
AP 1 Delay Mean 25.2200 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 76.9200 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 52.0150 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -12.5000 %
Steady State Accommodation Mean -12.5000 %
Accommodation Rate to Steady State -0.0131 %/ms
Accommodation at Steady State Mean -19.4488 %
Accommodation Rate Mean at Steady State 1326.3569 ms
ISI CV 20.3777
ISI Median 57.7950 ms
ISI Burst Mean Change 1.2186 %
Spike Rate (Strong Stimulation) 34.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 8.7100 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 35.1900 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 27.0050 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2087.7500 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 74.2250 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 19673.4 µm2
Number of Stems 10.0
Number of Bifurcations 32.0
Number of Branches 73.0
Overall Width 230.601 µm
Overall Height 377.48 µm
Overall Depth 216.46 µm
Average Diameter 0.957682 µm
Total Length 3674.86 µm
Total Surface 9817.45 µm2
Total Volume 7793.67 µm3
Max Euclidean Distance 293.169 µm
Max Path Distance 331.789 µm
Max Branch Order 5.0
Average Contraction 0.961425
Total Fragmentation 2742.0
Partition Asymmetry 0.458333
Average Rall's Ratio 1.07705
Average Bifurcation Angle Local 14.5791 °
Average Bifurcation Angle Remote 61.6353 °
Fractal Dimension 1.00959
Complexity Summary
State Equations 1861
Optimal Time-Step 0.00774 ms
Relative Complexity 436.03 HH
Model Size
Sections 72
Compartments 184
State Equations 1861
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00774 ms
Optimal Time-Step Error 0.18 %
Optimal Time-Step Benchmark Run Time 436.03 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 1.02 %
Max. Stable Time-Step Benchmark Run Time 843.26 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 13787 Hz
CVODE Steps Per AP 480
CVODE Benchmark Run Time 412.30 HH
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