Layer 6 Continuous Non-accommodating Nest Basket Cell (1)

Model Type:
Cell
Neurolex IDs: Neocortex basket cell
Neocortex Layer 6
Keywords: continuous non-accommodating,Layer 6,Fast-spiking, interneuron, GABAergic, inhibitory, neocortex, rat, somatosensory cortex, nest, basket
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000927
cNAC187_L6_NBC_4225ab5b52_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000927
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Non-accommodating Regular Spikers (naRS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -69.06 mV
Rheobase Current Interval (0.01236, 0.01282] nA
Threshold Current Interval (0.05859, 0.11719] nA
Bias Current (to -80.00 mV) -0.0133 nA
Testing Temperature 34.0 °C
Stability Interval [-0.625, 15.0] nA
AP 1-2 Amplitude Drop -0.2780 mV
AP 1 Steady State Amplitude Change -0.1209 mV
AP 1 Amplitude 71.3409 mV
AP 1 Width at Half Height 0.6700 ms
AP 1 Width (Peak To Trough) 5.1200 ms
AP 1 Rate of Change Peak to Trough -18.4571 mV/ms
AP 1 AHP Depth 23.1592 mV
AP2 Amplitude 71.6190 mV
AP2 Width at Half Height 0.6700 ms
AP 2 Width (Peak to Trough) 5.2900 ms
AP 2 Rate of Change Peak to Trough -17.8465 mV/ms
AP 2 AHP Depth 22.7892 mV
AP 1-2 Amplitude Change Percent 0.3897 %
AP 1-2 Half Width Change Percent 0.0000 %
AP 1-2 Rate of Change Peak to Trough Percent Change -3.3078 %
AP 1-2 AHP Depth Percent Change -1.5975 %
Input Resistance 811.7271 MΩ
AP 1 Delay Mean 33.8100 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 97.7300 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 64.2750 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -16.6667 %
Steady State Accommodation Mean -16.6667 %
Accommodation Rate to Steady State -0.0168 %/ms
Accommodation at Steady State Mean -21.4507 %
Accommodation Rate Mean at Steady State 1232.1872 ms
ISI CV 17.6735
ISI Median 72.5800 ms
ISI Burst Mean Change 1.1108 %
Spike Rate (Strong Stimulation) 27.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 12.3200 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 45.1800 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 33.2100 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2127.6600 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 45.3904 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 3574.64 µm2
Number of Stems 10.0
Number of Bifurcations 15.0
Number of Branches 39.0
Overall Width 289.203 µm
Overall Height 320.153 µm
Overall Depth 113.37 µm
Average Diameter 0.538793 µm
Total Length 2578.16 µm
Total Surface 3688.16 µm2
Total Volume 1335.62 µm3
Max Euclidean Distance 241.616 µm
Max Path Distance 290.404 µm
Max Branch Order 4.0
Average Contraction 0.966898
Total Fragmentation 1198.0
Partition Asymmetry 0.266667
Average Rall's Ratio 1.58444
Average Bifurcation Angle Local 48.306 °
Average Bifurcation Angle Remote 57.3148 °
Fractal Dimension 1.00605
Complexity Summary
State Equations 1281
Optimal Time-Step 0.00775 ms
Relative Complexity 309.52 HH
Model Size
Sections 40
Compartments 126
State Equations 1281
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00775 ms
Optimal Time-Step Error 0.16 %
Optimal Time-Step Benchmark Run Time 309.52 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 0.82 %
Max. Stable Time-Step Benchmark Run Time 599.75 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 14935 Hz
CVODE Steps Per AP 476
CVODE Benchmark Run Time 310.74 HH
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