Layer 6 Continuous Non-accommodating Martinotti Cell (5)

Model Type:
Cell
Neurolex IDs: Martinotti Cell
Neocortex Layer 6
Keywords: continuous non-accommodating,Layer 6,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, Martinotti
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000926
cNAC187_L6_MC_df869132b9_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000926
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Non-accommodating Regular Spikers (naRS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -68.87 mV
Rheobase Current Interval (0.02861, 0.02975] nA
Threshold Current Interval (0.23438, 0.29297] nA
Bias Current (to -80.00 mV) -0.0260 nA
Testing Temperature 34.0 °C
Stability Interval [-2.1875, 15.0] nA
AP 1-2 Amplitude Drop 0.1237 mV
AP 1 Steady State Amplitude Change 0.1656 mV
AP 1 Amplitude 68.0292 mV
AP 1 Width at Half Height 0.7100 ms
AP 1 Width (Peak To Trough) 7.8700 ms
AP 1 Rate of Change Peak to Trough -10.6550 mV/ms
AP 1 AHP Depth 15.8260 mV
AP2 Amplitude 67.9055 mV
AP2 Width at Half Height 0.7000 ms
AP 2 Width (Peak to Trough) 7.8900 ms
AP 2 Rate of Change Peak to Trough -10.6181 mV/ms
AP 2 AHP Depth 15.8709 mV
AP 1-2 Amplitude Change Percent -0.1818 %
AP 1-2 Half Width Change Percent -1.4085 %
AP 1-2 Rate of Change Peak to Trough Percent Change -0.3472 %
AP 1-2 AHP Depth Percent Change 0.2837 %
Input Resistance 438.7708 MΩ
AP 1 Delay Mean 32.7000 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 92.0000 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 59.5500 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -14.2857 %
Steady State Accommodation Mean -14.2857 %
Accommodation Rate to Steady State -0.0204 %/ms
Accommodation at Steady State Mean -13.0488 %
Accommodation Rate Mean at Steady State 1663.2665 ms
ISI CV 34.9705
ISI Median 63.0900 ms
ISI Burst Mean Change 0.8432 %
Spike Rate (Strong Stimulation) 32.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 11.9400 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 41.4400 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 30.1450 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2076.7400 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 92.2826 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 7984.76 µm2
Number of Stems 5.0
Number of Bifurcations 82.0
Number of Branches 168.0
Overall Width 261.682 µm
Overall Height 380.773 µm
Overall Depth 109.47 µm
Average Diameter 0.536782 µm
Total Length 5554.02 µm
Total Surface 8549.8 µm2
Total Volume 3567.27 µm3
Max Euclidean Distance 282.13 µm
Max Path Distance 321.954 µm
Max Branch Order 14.0
Average Contraction 0.972002
Total Fragmentation 2728.0
Partition Asymmetry 0.540437
Average Rall's Ratio 1.40342
Average Bifurcation Angle Local 44.7908 °
Average Bifurcation Angle Remote 59.0145 °
Fractal Dimension 1.00509
Complexity Summary
State Equations 3031
Optimal Time-Step 0.00763 ms
Relative Complexity 757.26 HH
Model Size
Sections 167
Compartments 301
State Equations 3031
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00763 ms
Optimal Time-Step Error 0.27 %
Optimal Time-Step Benchmark Run Time 757.26 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 1.31 %
Max. Stable Time-Step Benchmark Run Time 1444.72 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 13200 Hz
CVODE Steps Per AP 544
CVODE Benchmark Run Time 708.53 HH
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