Layer 6 Continuous Non-accommodating Martinotti Cell (3)

Model Type:
Cell
Neurolex IDs: Martinotti Cell
Neocortex Layer 6
Keywords: continuous non-accommodating,Layer 6,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, Martinotti
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000924
cNAC187_L6_MC_8f46a0ad62_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000924
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Non-accommodating Regular Spikers (naRS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -67.91 mV
Rheobase Current Interval (0.03845, 0.03983] nA
Threshold Current Interval (0.29297, 0.35156] nA
Bias Current (to -80.00 mV) -0.0457 nA
Testing Temperature 34.0 °C
Stability Interval [-2.8125, 15.0] nA
AP 1-2 Amplitude Drop 4.3210 mV
AP 1 Steady State Amplitude Change 1.1857 mV
AP 1 Amplitude 57.1958 mV
AP 1 Width at Half Height 0.7100 ms
AP 1 Width (Peak To Trough) 4.4900 ms
AP 1 Rate of Change Peak to Trough -17.4402 mV/ms
AP 1 AHP Depth 21.1108 mV
AP2 Amplitude 52.8748 mV
AP2 Width at Half Height 0.7400 ms
AP 2 Width (Peak to Trough) 4.9600 ms
AP 2 Rate of Change Peak to Trough -14.8958 mV/ms
AP 2 AHP Depth 21.0086 mV
AP 1-2 Amplitude Change Percent -7.5547 %
AP 1-2 Half Width Change Percent 4.2254 %
AP 1-2 Rate of Change Peak to Trough Percent Change -14.5892 %
AP 1-2 AHP Depth Percent Change -0.4845 %
Input Resistance 277.0176 MΩ
AP 1 Delay Mean 46.6100 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 119.3800 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 72.4600 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean 0.0000 %
Steady State Accommodation Mean 0.0000 %
Accommodation Rate to Steady State 0.0000 %/ms
Accommodation at Steady State Mean -99.7337 %
Accommodation Rate Mean at Steady State 9885246.4146 ms
ISI CV 48.0779
ISI Median 74.1750 ms
ISI Burst Mean Change -0.8520 %
Spike Rate (Strong Stimulation) 30.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 16.3300 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 48.4300 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 32.8950 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2116.9400 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 58.3542 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 11567.1 µm2
Number of Stems 8.0
Number of Bifurcations 43.0
Number of Branches 93.0
Overall Width 554.264 µm
Overall Height 632.038 µm
Overall Depth 331.92 µm
Average Diameter 0.870208 µm
Total Length 7351.36 µm
Total Surface 14256.8 µm2
Total Volume 6400.0 µm3
Max Euclidean Distance 531.584 µm
Max Path Distance 741.656 µm
Max Branch Order 9.0
Average Contraction 0.961839
Total Fragmentation 2885.0
Partition Asymmetry 0.450321
Average Rall's Ratio 1.2056
Average Bifurcation Angle Local 12.5362 °
Average Bifurcation Angle Remote 41.2918 °
Fractal Dimension 1.00721
Complexity Summary
State Equations 3621
Optimal Time-Step 0.00535 ms
Relative Complexity 1253.99 HH
Model Size
Sections 94
Compartments 360
State Equations 3621
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00535 ms
Optimal Time-Step Error 0.10 %
Optimal Time-Step Benchmark Run Time 1253.99 HH
 
Maximum Stable Time-Step 0.03125 ms
Maximum Stable Time-Step Error 0.83 %
Max. Stable Time-Step Benchmark Run Time 3350.87 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 28658 Hz
CVODE Steps Per AP -88
CVODE Benchmark Run Time 1223.99 HH
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