Layer 6 Continuous Non-accommodating Double Bouquet Cell (1)

Model Type:
Cell
Neurolex IDs: Double Bouquet Cell
Neocortex Layer 6
Keywords: continuous non-accommodating,Layer 6,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, double bouquet, biophysical, continuous non-accommodating double bouquet cell, Realistic Network, Neuron or other electrically excitable cell, Synapse, Spatio-temporal Activity Patterns, Detailed Neuronal Models
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000912
cNAC187_L6_DBC_166d3f579a_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000912
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Non-accommodating Regular Spikers (naRS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -67.82 mV
Rheobase Current Interval (0.03296, 0.03387] nA
Threshold Current Interval (0.17578, 0.23438] nA
Bias Current (to -80.00 mV) -0.0363 nA
Testing Temperature 34.0 °C
Stability Interval [-1.5625, 15.0] nA
AP 1-2 Amplitude Drop 1.2188 mV
AP 1 Steady State Amplitude Change 1.7511 mV
AP 1 Amplitude 63.3460 mV
AP 1 Width at Half Height 0.7400 ms
AP 1 Width (Peak To Trough) 4.8900 ms
AP 1 Rate of Change Peak to Trough -14.9463 mV/ms
AP 1 AHP Depth 9.7416 mV
AP2 Amplitude 62.1271 mV
AP2 Width at Half Height 0.7600 ms
AP 2 Width (Peak to Trough) 5.3600 ms
AP 2 Rate of Change Peak to Trough -13.4455 mV/ms
AP 2 AHP Depth 9.9410 mV
AP 1-2 Amplitude Change Percent -1.9241 %
AP 1-2 Half Width Change Percent 2.7027 %
AP 1-2 Rate of Change Peak to Trough Percent Change -10.0411 %
AP 1-2 AHP Depth Percent Change 2.0474 %
Input Resistance 345.6956 MΩ
AP 1 Delay Mean 27.5700 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 76.3900 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 49.0700 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean 0.0000 %
Steady State Accommodation Mean 0.0000 %
Accommodation Rate to Steady State 0.0000 %/ms
Accommodation at Steady State Mean -99.8703 %
Accommodation Rate Mean at Steady State 32195945.5319 ms
ISI CV 74.4946
ISI Median 49.8900 ms
ISI Burst Mean Change 1.0242 %
Spike Rate (Strong Stimulation) 40.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 9.4500 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 33.2300 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 24.8000 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2083.6900 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 72.3519 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 8381.24 µm2
Number of Stems 5.0
Number of Bifurcations 37.0
Number of Branches 78.0
Overall Width 176.043 µm
Overall Height 962.998 µm
Overall Depth 201.34 µm
Average Diameter 0.900764 µm
Total Length 4470.81 µm
Total Surface 11833.9 µm2
Total Volume 6036.6 µm3
Max Euclidean Distance 803.948 µm
Max Path Distance 846.713 µm
Max Branch Order 16.0
Average Contraction 0.962225
Total Fragmentation 4757.0
Partition Asymmetry 0.636207
Average Rall's Ratio 0.690357
Average Bifurcation Angle Local 39.1521 °
Average Bifurcation Angle Remote 57.0439 °
Fractal Dimension 1.00829
Complexity Summary
Relative Complexity 497.89 HH
State Equations 2271
Optimal Time-Step 0.00543 ms
Model Size
Sections 79
Compartments 225
State Equations 2271
Variable Time-Step Complexity
CVODE Steady State Step Frequency 13881 Hz
CVODE Steps Per AP 469
CVODE Benchmark Run Time 497.89 HH
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