Layer 6 Continuous Non-accommodating Chandelier Cell (5)

Model Type:
Cell
Neurolex IDs: Neocortex Layer 6
Chandelier Cell
Keywords: continuous non-accommodating,Layer 6,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, chandelier
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000911
cNAC187_L6_ChC_d1b33e54c2_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000911
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Non-accommodating Regular Spikers (naRS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -68.50 mV
Rheobase Current Interval (0.01923, 0.02014] nA
Threshold Current Interval (0.17578, 0.23438] nA
Bias Current (to -80.00 mV) -0.0270 nA
Testing Temperature 34.0 °C
Stability Interval [-2.1875, 15.0] nA
AP 1-2 Amplitude Drop 0.1851 mV
AP 1 Steady State Amplitude Change 0.2020 mV
AP 1 Amplitude 66.2338 mV
AP 1 Width at Half Height 0.7400 ms
AP 1 Width (Peak To Trough) 6.7100 ms
AP 1 Rate of Change Peak to Trough -12.3604 mV/ms
AP 1 AHP Depth 16.7042 mV
AP2 Amplitude 66.0488 mV
AP2 Width at Half Height 0.7400 ms
AP 2 Width (Peak to Trough) 6.6800 ms
AP 2 Rate of Change Peak to Trough -12.4065 mV/ms
AP 2 AHP Depth 16.8270 mV
AP 1-2 Amplitude Change Percent -0.2794 %
AP 1-2 Half Width Change Percent 0.0000 %
AP 1-2 Rate of Change Peak to Trough Percent Change 0.3737 %
AP 1-2 AHP Depth Percent Change 0.7350 %
Input Resistance 443.1066 MΩ
AP 1 Delay Mean 51.5300 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 134.0800 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 82.8550 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean 0.0000 %
Steady State Accommodation Mean 0.0000 %
Accommodation Rate to Steady State 0.0000 %/ms
Accommodation at Steady State Mean -13.6073 %
Accommodation Rate Mean at Steady State 1516.4174 ms
ISI CV 31.8476
ISI Median 88.2100 ms
ISI Burst Mean Change 0.7389 %
Spike Rate (Strong Stimulation) 25.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 18.0800 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 56.4800 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 38.8500 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2126.3400 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 54.4531 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 5852.68 µm2
Number of Stems 9.0
Number of Bifurcations 42.0
Number of Branches 92.0
Overall Width 328.788 µm
Overall Height 402.328 µm
Overall Depth 246.14 µm
Average Diameter 0.816843 µm
Total Length 3868.59 µm
Total Surface 8644.52 µm2
Total Volume 3449.34 µm3
Max Euclidean Distance 331.063 µm
Max Path Distance 399.318 µm
Max Branch Order 6.0
Average Contraction 0.95134
Total Fragmentation 2523.0
Partition Asymmetry 0.492435
Average Rall's Ratio 0.857407
Average Bifurcation Angle Local 38.7425 °
Average Bifurcation Angle Remote 59.3805 °
Fractal Dimension 1.01088
Complexity Summary
State Equations 2081
Optimal Time-Step 0.00774 ms
Relative Complexity 502.64 HH
Model Size
Sections 92
Compartments 206
State Equations 2081
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00774 ms
Optimal Time-Step Error 0.15 %
Optimal Time-Step Benchmark Run Time 502.64 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 0.90 %
Max. Stable Time-Step Benchmark Run Time 972.12 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 14922 Hz
CVODE Steps Per AP 423
CVODE Benchmark Run Time 489.72 HH
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