Layer 6 Continuous Non-accommodating Chandelier Cell (1)

Model Type:
Cell
Neurolex IDs: Neocortex Layer 6
Chandelier Cell
Keywords: continuous non-accommodating,Layer 6,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, chandelier
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000907
cNAC187_L6_ChC_44806c5355_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000907
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Non-accommodating Regular Spikers (naRS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -68.46 mV
Rheobase Current Interval (0.02174, 0.02289] nA
Threshold Current Interval (0.23438, 0.29297] nA
Bias Current (to -80.00 mV) -0.0324 nA
Testing Temperature 34.0 °C
Stability Interval [-1.5625, 15.0] nA
AP 1-2 Amplitude Drop 0.1954 mV
AP 1 Steady State Amplitude Change 0.1990 mV
AP 1 Amplitude 72.9568 mV
AP 1 Width at Half Height 0.5700 ms
AP 1 Width (Peak To Trough) 3.9200 ms
AP 1 Rate of Change Peak to Trough -25.1385 mV/ms
AP 1 AHP Depth 25.5861 mV
AP2 Amplitude 72.7615 mV
AP2 Width at Half Height 0.5600 ms
AP 2 Width (Peak to Trough) 3.9100 ms
AP 2 Rate of Change Peak to Trough -25.1967 mV/ms
AP 2 AHP Depth 25.7575 mV
AP 1-2 Amplitude Change Percent -0.2678 %
AP 1-2 Half Width Change Percent -1.7544 %
AP 1-2 Rate of Change Peak to Trough Percent Change 0.2314 %
AP 1-2 AHP Depth Percent Change 0.6699 %
Input Resistance 355.3870 MΩ
AP 1 Delay Mean 46.8900 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 126.2000 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 79.7150 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -20.0000 %
Steady State Accommodation Mean -20.0000 %
Accommodation Rate to Steady State -0.0229 %/ms
Accommodation at Steady State Mean -16.9342 %
Accommodation Rate Mean at Steady State 1309.2693 ms
ISI CV 23.6489
ISI Median 86.9900 ms
ISI Burst Mean Change 1.0213 %
Spike Rate (Strong Stimulation) 24.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 16.1300 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 54.2900 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 38.4600 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2162.4900 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 80.0746 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 8533.04 µm2
Number of Stems 6.0
Number of Bifurcations 26.0
Number of Branches 57.0
Overall Width 342.883 µm
Overall Height 591.634 µm
Overall Depth 170.66 µm
Average Diameter 0.974032 µm
Total Length 2774.76 µm
Total Surface 8893.81 µm2
Total Volume 4825.19 µm3
Max Euclidean Distance 417.861 µm
Max Path Distance 469.494 µm
Max Branch Order 11.0
Average Contraction 0.930909
Total Fragmentation 2370.0
Partition Asymmetry 0.571072
Average Rall's Ratio 0.891538
Average Bifurcation Angle Local 44.4674 °
Average Bifurcation Angle Remote 74.2266 °
Fractal Dimension 1.01179
Complexity Summary
State Equations 1561
Optimal Time-Step 0.00767 ms
Relative Complexity 381.64 HH
Model Size
Sections 60
Compartments 154
State Equations 1561
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00767 ms
Optimal Time-Step Error 0.03 %
Optimal Time-Step Benchmark Run Time 381.64 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 0.46 %
Max. Stable Time-Step Benchmark Run Time 731.59 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 14987 Hz
CVODE Steps Per AP 478
CVODE Benchmark Run Time 380.57 HH
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