Layer 5 Continuous Non-accommodating Large Basket Cell (2)

Model Type:
Cell
Neurolex IDs: Neocortex basket cell
Neocortex Layer 5
Keywords: continuous non-accommodating,Layer 5,Fast-spiking, interneuron, GABAergic, inhibitory, neocortex, rat, somatosensory cortex, large, basket
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000878
cNAC187_L5_LBC_1e4112fe69_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000878
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Non-accommodating Regular Spikers (naRS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -68.48 mV
Rheobase Current Interval (0.04005, 0.04166] nA
Threshold Current Interval (0.35156, 0.41016] nA
Bias Current (to -80.00 mV) -0.0413 nA
Testing Temperature 34.0 °C
Stability Interval [-3.125, 15.0] nA
AP 1-2 Amplitude Drop -0.1137 mV
AP 1 Steady State Amplitude Change 0.0514 mV
AP 1 Amplitude 63.4854 mV
AP 1 Width at Half Height 0.7700 ms
AP 1 Width (Peak To Trough) 8.8200 ms
AP 1 Rate of Change Peak to Trough -8.5611 mV/ms
AP 1 AHP Depth 12.0239 mV
AP2 Amplitude 63.5991 mV
AP2 Width at Half Height 0.7700 ms
AP 2 Width (Peak to Trough) 8.9000 ms
AP 2 Rate of Change Peak to Trough -8.4730 mV/ms
AP 2 AHP Depth 11.8108 mV
AP 1-2 Amplitude Change Percent 0.1791 %
AP 1-2 Half Width Change Percent 0.0000 %
AP 1-2 Rate of Change Peak to Trough Percent Change -1.0293 %
AP 1-2 AHP Depth Percent Change -1.7725 %
Input Resistance 292.4564 MΩ
AP 1 Delay Mean 40.7700 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 105.6100 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 65.0250 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean 0.0000 %
Steady State Accommodation Mean 0.0000 %
Accommodation Rate to Steady State 0.0000 %/ms
Accommodation at Steady State Mean -99.0738 %
Accommodation Rate Mean at Steady State 3821424.9790 ms
ISI CV 65.4183
ISI Median 66.4300 ms
ISI Burst Mean Change 0.5706 %
Spike Rate (Strong Stimulation) 32.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 14.2100 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 43.9100 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 30.5800 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2083.6400 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 105.4033 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 10882.0 µm2
Number of Stems 10.0
Number of Bifurcations 72.0
Number of Branches 153.0
Overall Width 336.8 µm
Overall Height 437.942 µm
Overall Depth 210.68 µm
Average Diameter 0.681724 µm
Total Length 7775.71 µm
Total Surface 14234.0 µm2
Total Volume 5393.69 µm3
Max Euclidean Distance 438.036 µm
Max Path Distance 478.316 µm
Max Branch Order 10.0
Average Contraction 0.956724
Total Fragmentation 5000.0
Partition Asymmetry 0.509792
Average Rall's Ratio 1.43685
Average Bifurcation Angle Local 23.068 °
Average Bifurcation Angle Remote 63.6682 °
Fractal Dimension 1.00866
Complexity Summary
State Equations 4061
Optimal Time-Step 0.00786 ms
Relative Complexity 1044.38 HH
Model Size
Sections 156
Compartments 404
State Equations 4061
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00786 ms
Optimal Time-Step Error 0.22 %
Optimal Time-Step Benchmark Run Time 1044.38 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 2.04 %
Max. Stable Time-Step Benchmark Run Time 2052.67 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 13268 Hz
CVODE Steps Per AP 460
CVODE Benchmark Run Time 964.97 HH
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