Layer 5 Continuous Non-accommodating Large Basket Cell (1)

Model Type:
Cell
Neurolex IDs: Neocortex basket cell
Neocortex Layer 5
Keywords: continuous non-accommodating,Layer 5,Fast-spiking, interneuron, GABAergic, inhibitory, neocortex, rat, somatosensory cortex, large, basket, biophysical, continuous non-accommodating large basket cell, Realistic Network, Neuron or other electrically excitable cell, Synapse, Spatio-temporal Activity Patterns, Detailed Neuronal Models
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000877
cNAC187_L5_LBC_078d827ab9_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000877
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Non-accommodating Regular Spikers (naRS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -68.43 mV
Rheobase Current Interval (0.03845, 0.03983] nA
Threshold Current Interval (0.29297, 0.35156] nA
Bias Current (to -80.00 mV) -0.0411 nA
Testing Temperature 34.0 °C
Stability Interval [-2.1875, 15.0] nA
AP 1-2 Amplitude Drop 0.5166 mV
AP 1 Steady State Amplitude Change 0.5762 mV
AP 1 Amplitude 66.5066 mV
AP 1 Width at Half Height 0.7100 ms
AP 1 Width (Peak To Trough) 5.4000 ms
AP 1 Rate of Change Peak to Trough -15.5702 mV/ms
AP 1 AHP Depth 17.5723 mV
AP2 Amplitude 65.9899 mV
AP2 Width at Half Height 0.7100 ms
AP 2 Width (Peak to Trough) 5.4100 ms
AP 2 Rate of Change Peak to Trough -15.5125 mV/ms
AP 2 AHP Depth 17.9329 mV
AP 1-2 Amplitude Change Percent -0.7768 %
AP 1-2 Half Width Change Percent 0.0000 %
AP 1-2 Rate of Change Peak to Trough Percent Change -0.3701 %
AP 1-2 AHP Depth Percent Change 2.0522 %
Input Resistance 292.0539 MΩ
AP 1 Delay Mean 37.3100 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 102.2800 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 65.2050 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean 0.0000 %
Steady State Accommodation Mean 0.0000 %
Accommodation Rate to Steady State 0.0000 %/ms
Accommodation at Steady State Mean -13.2103 %
Accommodation Rate Mean at Steady State 1694.6536 ms
ISI CV 34.9655
ISI Median 69.0150 ms
ISI Burst Mean Change 0.7234 %
Spike Rate (Strong Stimulation) 30.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 12.9000 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 43.9900 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 31.6600 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2125.1800 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 60.6382 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 11887.7 µm2
Number of Stems 4.0
Number of Bifurcations 21.0
Number of Branches 45.0
Overall Width 502.72 µm
Overall Height 651.477 µm
Overall Depth 244.98 µm
Average Diameter 0.872344 µm
Total Length 5340.62 µm
Total Surface 12235.8 µm2
Total Volume 6082.95 µm3
Max Euclidean Distance 419.078 µm
Max Path Distance 512.709 µm
Max Branch Order 6.0
Average Contraction 0.963661
Total Fragmentation 1125.0
Partition Asymmetry 0.401361
Average Rall's Ratio 1.48286
Average Bifurcation Angle Local 56.909 °
Average Bifurcation Angle Remote 76.4229 °
Fractal Dimension 1.00591
Complexity Summary
Relative Complexity 585.16 HH
State Equations 2701
Optimal Time-Step 0.00783 ms
Model Size
Sections 46
Compartments 268
State Equations 2701
Variable Time-Step Complexity
CVODE Steady State Step Frequency 14495 Hz
CVODE Steps Per AP 407
CVODE Benchmark Run Time 585.16 HH
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