Layer 5 Continuous Non-accommodating Double Bouquet Cell (1)

Model Type:
Cell
Neurolex IDs: Double Bouquet Cell
Neocortex Layer 5
Keywords: continuous non-accommodating,Layer 5,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, double bouquet
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000872
cNAC187_L5_DBC_893b78d08e_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000872
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Non-accommodating Regular Spikers (naRS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -67.64 mV
Rheobase Current Interval (0.03296, 0.03479] nA
Threshold Current Interval (0.41016, 0.46875] nA
Bias Current (to -80.00 mV) -0.0573 nA
Testing Temperature 34.0 °C
Stability Interval [-4.0625, 15.0] nA
AP 1-2 Amplitude Drop 0.0434 mV
AP 1 Steady State Amplitude Change 0.1604 mV
AP 1 Amplitude 61.6237 mV
AP 1 Width at Half Height 0.8000 ms
AP 1 Width (Peak To Trough) 7.0200 ms
AP 1 Rate of Change Peak to Trough -10.7348 mV/ms
AP 1 AHP Depth 13.7349 mV
AP2 Amplitude 61.5803 mV
AP2 Width at Half Height 0.8100 ms
AP 2 Width (Peak to Trough) 6.9200 ms
AP 2 Rate of Change Peak to Trough -10.8720 mV/ms
AP 2 AHP Depth 13.6538 mV
AP 1-2 Amplitude Change Percent -0.0704 %
AP 1-2 Half Width Change Percent 1.2500 %
AP 1-2 Rate of Change Peak to Trough Percent Change 1.2774 %
AP 1-2 AHP Depth Percent Change -0.5908 %
Input Resistance 238.5751 MΩ
AP 1 Delay Mean 62.3100 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 152.2500 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 90.0650 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean 0.0000 %
Steady State Accommodation Mean 0.0000 %
Accommodation Rate to Steady State 0.0000 %/ms
Accommodation at Steady State Mean -29.9426 %
Accommodation Rate Mean at Steady State 11733.0724 ms
ISI CV 56.8262
ISI Median 92.4700 ms
ISI Burst Mean Change 0.2780 %
Spike Rate (Strong Stimulation) 25.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 21.2900 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 60.1300 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 39.4300 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2143.3900 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 93.1032 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 9840.66 µm2
Number of Stems 7.0
Number of Bifurcations 36.0
Number of Branches 78.0
Overall Width 327.082 µm
Overall Height 694.266 µm
Overall Depth 140.34 µm
Average Diameter 1.21329 µm
Total Length 4987.37 µm
Total Surface 17795.3 µm2
Total Volume 7725.38 µm3
Max Euclidean Distance 581.386 µm
Max Path Distance 589.86 µm
Max Branch Order 7.0
Average Contraction 0.968757
Total Fragmentation 1862.0
Partition Asymmetry 0.477888
Average Rall's Ratio 1.82983
Average Bifurcation Angle Local 24.2321 °
Average Bifurcation Angle Remote 42.9422 °
Fractal Dimension 1.00527
Complexity Summary
State Equations 2471
Optimal Time-Step 0.00771 ms
Relative Complexity 597.58 HH
Model Size
Sections 81
Compartments 245
State Equations 2471
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00771 ms
Optimal Time-Step Error 0.07 %
Optimal Time-Step Benchmark Run Time 597.58 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 0.64 %
Max. Stable Time-Step Benchmark Run Time 1151.51 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 14465 Hz
CVODE Steps Per AP 327
CVODE Benchmark Run Time 537.23 HH
Website & Images Copyright NeuroML © 2020 For questions: Contact us Links: Search Test |  ModelDB WS