Layer 5 Continuous Non-accommodating Bitufted Cell (2)

Model Type:
Cell
Neurolex IDs: Neocortex Layer 5
Keywords: continuous non-accommodating,Layer 5,Rat, somatosensory cortex, bitufted
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000863
cNAC187_L5_BTC_18584bfae6_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000863
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Non-accommodating Regular Spikers (naRS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -67.97 mV
Rheobase Current Interval (0.03021, 0.03159] nA
Threshold Current Interval (0.29297, 0.35156] nA
Bias Current (to -80.00 mV) -0.0435 nA
Testing Temperature 34.0 °C
Stability Interval [-3.125, 15.0] nA
AP 1-2 Amplitude Drop -0.0968 mV
AP 1 Steady State Amplitude Change 0.3975 mV
AP 1 Amplitude 68.5308 mV
AP 1 Width at Half Height 0.6500 ms
AP 1 Width (Peak To Trough) 11.3800 ms
AP 1 Rate of Change Peak to Trough -6.9150 mV/ms
AP 1 AHP Depth 10.1619 mV
AP2 Amplitude 68.6276 mV
AP2 Width at Half Height 0.6500 ms
AP 2 Width (Peak to Trough) 11.4200 ms
AP 2 Rate of Change Peak to Trough -6.8820 mV/ms
AP 2 AHP Depth 9.9644 mV
AP 1-2 Amplitude Change Percent 0.1413 %
AP 1-2 Half Width Change Percent 0.0000 %
AP 1-2 Rate of Change Peak to Trough Percent Change -0.4777 %
AP 1-2 AHP Depth Percent Change -1.9433 %
Input Resistance 302.8254 MΩ
AP 1 Delay Mean 56.4200 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 135.1500 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 78.8000 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean 0.0000 %
Steady State Accommodation Mean 0.0000 %
Accommodation Rate to Steady State 0.0000 %/ms
Accommodation at Steady State Mean -99.4216 %
Accommodation Rate Mean at Steady State 9268847.2708 ms
ISI CV 95.4889
ISI Median 79.3250 ms
ISI Burst Mean Change 0.1778 %
Spike Rate (Strong Stimulation) 30.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 18.9000 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 51.7000 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 33.7850 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2133.1300 ms
Frequency Filter Type Constant
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 7202.41 µm2
Number of Stems 3.0
Number of Bifurcations 66.0
Number of Branches 134.0
Overall Width 328.788 µm
Overall Height 564.381 µm
Overall Depth 312.8 µm
Average Diameter 0.762465 µm
Total Length 7107.33 µm
Total Surface 15024.4 µm2
Total Volume 4439.21 µm3
Max Euclidean Distance 407.84 µm
Max Path Distance 423.921 µm
Max Branch Order 11.0
Average Contraction 0.971867
Total Fragmentation 1523.0
Partition Asymmetry 0.562991
Average Rall's Ratio 1.941
Average Bifurcation Angle Local 42.473 °
Average Bifurcation Angle Remote 59.6696 °
Fractal Dimension 1.00325
Complexity Summary
State Equations 3661
Optimal Time-Step 0.00765 ms
Relative Complexity 980.70 HH
Model Size
Sections 136
Compartments 364
State Equations 3661
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00765 ms
Optimal Time-Step Error 0.11 %
Optimal Time-Step Benchmark Run Time 980.70 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 0.73 %
Max. Stable Time-Step Benchmark Run Time 1874.40 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 14045 Hz
CVODE Steps Per AP 359
CVODE Benchmark Run Time 869.61 HH
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