Layer 5 Continuous Non-accommodating Bitufted Cell (1)

Model Type:
Cell
Neurolex IDs: Neocortex Layer 5
Keywords: continuous non-accommodating,Layer 5,Rat, somatosensory cortex, bitufted
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000862
cNAC187_L5_BTC_0a43e2f3e5_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000862
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Non-accommodating Regular Spikers (naRS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -68.42 mV
Rheobase Current Interval (0.01740, 0.01831] nA
Threshold Current Interval (0.17578, 0.23438] nA
Bias Current (to -80.00 mV) -0.0235 nA
Testing Temperature 34.0 °C
Stability Interval [-1.25, 15.0] nA
AP 1-2 Amplitude Drop 0.0037 mV
AP 1 Steady State Amplitude Change 0.0608 mV
AP 1 Amplitude 71.8405 mV
AP 1 Width at Half Height 0.6900 ms
AP 1 Width (Peak To Trough) 3.6500 ms
AP 1 Rate of Change Peak to Trough -24.2913 mV/ms
AP 1 AHP Depth 16.8229 mV
AP2 Amplitude 71.8368 mV
AP2 Width at Half Height 0.6900 ms
AP 2 Width (Peak to Trough) 3.6500 ms
AP 2 Rate of Change Peak to Trough -24.2682 mV/ms
AP 2 AHP Depth 16.7420 mV
AP 1-2 Amplitude Change Percent -0.0051 %
AP 1-2 Half Width Change Percent 0.0000 %
AP 1-2 Rate of Change Peak to Trough Percent Change -0.0953 %
AP 1-2 AHP Depth Percent Change -0.4806 %
Input Resistance 523.1715 MΩ
AP 1 Delay Mean 48.4000 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 126.4400 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 78.3150 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean 0.0000 %
Steady State Accommodation Mean 0.0000 %
Accommodation Rate to Steady State 0.0000 %/ms
Accommodation at Steady State Mean -12.9045 %
Accommodation Rate Mean at Steady State 1639.5360 ms
ISI CV 35.3965
ISI Median 82.7700 ms
ISI Burst Mean Change 0.7048 %
Spike Rate (Strong Stimulation) 26.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 16.6000 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 52.7000 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 36.6150 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2130.1400 ms
Frequency Filter Type Constant
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 4079.79 µm2
Number of Stems 4.0
Number of Bifurcations 21.0
Number of Branches 45.0
Overall Width 350.886 µm
Overall Height 370.815 µm
Overall Depth 240.77 µm
Average Diameter 0.94211 µm
Total Length 3146.63 µm
Total Surface 7520.99 µm2
Total Volume 2688.77 µm3
Max Euclidean Distance 305.648 µm
Max Path Distance 402.234 µm
Max Branch Order 5.0
Average Contraction 0.934027
Total Fragmentation 699.0
Partition Asymmetry 0.212585
Average Rall's Ratio 1.9715
Average Bifurcation Angle Local 59.2515 °
Average Bifurcation Angle Remote 64.3666 °
Fractal Dimension 1.00437
Complexity Summary
State Equations 1581
Optimal Time-Step 0.00765 ms
Relative Complexity 380.58 HH
Model Size
Sections 46
Compartments 156
State Equations 1581
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00765 ms
Optimal Time-Step Error 0.08 %
Optimal Time-Step Benchmark Run Time 380.58 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 0.81 %
Max. Stable Time-Step Benchmark Run Time 727.76 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 14643 Hz
CVODE Steps Per AP 451
CVODE Benchmark Run Time 366.66 HH
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