Layer 5 Continuous Non-accommodating Bipolar Cell (5)

Model Type:
Cell
Neurolex IDs: Bipolar Cell
Neocortex Layer 5
Keywords: continuous non-accommodating,Layer 5,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, bipolar
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000861
cNAC187_L5_BP_d97748152f_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000861
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Non-accommodating Regular Spikers (naRS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -67.94 mV
Rheobase Current Interval (0.01030, 0.01099] nA
Threshold Current Interval (0.11719, 0.17578] nA
Bias Current (to -80.00 mV) -0.0178 nA
Testing Temperature 34.0 °C
Stability Interval [-0.9375, 15.0] nA
AP 1-2 Amplitude Drop 0.2426 mV
AP 1 Steady State Amplitude Change 0.1899 mV
AP 1 Amplitude 72.4241 mV
AP 1 Width at Half Height 0.6400 ms
AP 1 Width (Peak To Trough) 3.3400 ms
AP 1 Rate of Change Peak to Trough -24.6534 mV/ms
AP 1 AHP Depth 9.9182 mV
AP2 Amplitude 72.1815 mV
AP2 Width at Half Height 0.6400 ms
AP 2 Width (Peak to Trough) 3.3200 ms
AP 2 Rate of Change Peak to Trough -24.7581 mV/ms
AP 2 AHP Depth 10.0155 mV
AP 1-2 Amplitude Change Percent -0.3350 %
AP 1-2 Half Width Change Percent 0.0000 %
AP 1-2 Rate of Change Peak to Trough Percent Change 0.4249 %
AP 1-2 AHP Depth Percent Change 0.9808 %
Input Resistance 749.2008 MΩ
AP 1 Delay Mean 59.5500 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 141.7400 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 82.3200 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean 0.0000 %
Steady State Accommodation Mean 0.0000 %
Accommodation Rate to Steady State 0.0000 %/ms
Accommodation at Steady State Mean -99.5426 %
Accommodation Rate Mean at Steady State 8496079.4531 ms
ISI CV 71.2237
ISI Median 83.8700 ms
ISI Burst Mean Change 0.3163 %
Spike Rate (Strong Stimulation) 28.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 20.8200 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 55.8700 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 35.9850 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2171.3000 ms
Frequency Filter Type Constant
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 1850.73 µm2
Number of Stems 5.0
Number of Bifurcations 30.0
Number of Branches 64.0
Overall Width 323.934 µm
Overall Height 465.446 µm
Overall Depth 224.45 µm
Average Diameter 0.633331 µm
Total Length 3669.61 µm
Total Surface 6421.02 µm2
Total Volume 1346.68 µm3
Max Euclidean Distance 335.545 µm
Max Path Distance 397.255 µm
Max Branch Order 6.0
Average Contraction 0.971379
Total Fragmentation 1022.0
Partition Asymmetry 0.369444
Average Rall's Ratio 1.11375
Average Bifurcation Angle Local 32.2461 °
Average Bifurcation Angle Remote 49.4585 °
Fractal Dimension 1.00557
Complexity Summary
State Equations 1871
Optimal Time-Step 0.00744 ms
Relative Complexity 476.71 HH
Model Size
Sections 65
Compartments 185
State Equations 1871
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00744 ms
Optimal Time-Step Error 0.07 %
Optimal Time-Step Benchmark Run Time 476.71 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 0.54 %
Max. Stable Time-Step Benchmark Run Time 886.62 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 15024 Hz
CVODE Steps Per AP 374
CVODE Benchmark Run Time 437.75 HH
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