Layer 4 Continuous Non-accommodating Neurogliaform Cell (2)

Model Type:
Cell
Neurolex IDs: Neocortex Layer 4
Keywords: continuous non-accommodating,Layer 4,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, neurogliaform
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000853
cNAC187_L4_NGC_226ca78646_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000853
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Non-accommodating Regular Spikers (naRS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -68.63 mV
Rheobase Current Interval (0.01831, 0.01945] nA
Threshold Current Interval (0.23438, 0.29297] nA
Bias Current (to -80.00 mV) -0.0249 nA
Testing Temperature 34.0 °C
Stability Interval [-1.875, 15.0] nA
AP 1-2 Amplitude Drop -0.0633 mV
AP 1 Steady State Amplitude Change 0.0769 mV
AP 1 Amplitude 58.9703 mV
AP 1 Width at Half Height 0.9800 ms
AP 1 Width (Peak To Trough) 12.4400 ms
AP 1 Rate of Change Peak to Trough -5.8367 mV/ms
AP 1 AHP Depth 13.6383 mV
AP2 Amplitude 59.0336 mV
AP2 Width at Half Height 0.9700 ms
AP 2 Width (Peak to Trough) 12.4700 ms
AP 2 Rate of Change Peak to Trough -5.8130 mV/ms
AP 2 AHP Depth 13.4546 mV
AP 1-2 Amplitude Change Percent 0.1073 %
AP 1-2 Half Width Change Percent -1.0204 %
AP 1-2 Rate of Change Peak to Trough Percent Change -0.4061 %
AP 1-2 AHP Depth Percent Change -1.3469 %
Input Resistance 478.0076 MΩ
AP 1 Delay Mean 58.2500 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 144.6000 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 86.5400 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean 0.0000 %
Steady State Accommodation Mean 0.0000 %
Accommodation Rate to Steady State 0.0000 %/ms
Accommodation at Steady State Mean -14.2300 %
Accommodation Rate Mean at Steady State 2583.9241 ms
ISI CV 41.3463
ISI Median 90.2900 ms
ISI Burst Mean Change 0.4401 %
Spike Rate (Strong Stimulation) 24.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 21.1000 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 60.7700 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 40.1500 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2165.5500 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 92.2291 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 5040.39 µm2
Number of Stems 6.0
Number of Bifurcations 57.0
Number of Branches 119.0
Overall Width 219.38 µm
Overall Height 197.006 µm
Overall Depth 225.65 µm
Average Diameter 0.686537 µm
Total Length 5312.15 µm
Total Surface 9235.18 µm2
Total Volume 2792.83 µm3
Max Euclidean Distance 204.045 µm
Max Path Distance 264.22 µm
Max Branch Order 6.0
Average Contraction 0.966929
Total Fragmentation 1382.0
Partition Asymmetry 0.314716
Average Rall's Ratio 1.42675
Average Bifurcation Angle Local 41.7374 °
Average Bifurcation Angle Remote 59.0734 °
Fractal Dimension 1.00519
Complexity Summary
State Equations 2741
Optimal Time-Step 0.00772 ms
Relative Complexity 671.27 HH
Model Size
Sections 120
Compartments 272
State Equations 2741
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00772 ms
Optimal Time-Step Error 0.07 %
Optimal Time-Step Benchmark Run Time 671.27 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 0.48 %
Max. Stable Time-Step Benchmark Run Time 1295.22 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 14962 Hz
CVODE Steps Per AP 378
CVODE Benchmark Run Time 638.59 HH
Website & Images Copyright NeuroML © 2019 For questions: Contact us Links: Search Test |  ModelDB WS