Layer 4 Continuous Non-accommodating Nest Basket Cell (1)

Model Type:
Cell
Neurolex IDs: Neocortex basket cell
Neocortex Layer 4
Keywords: continuous non-accommodating,Layer 4,Fast-spiking, interneuron, GABAergic, inhibitory, neocortex, rat, somatosensory cortex, nest, basket
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000847
cNAC187_L4_NBC_0bf743ff25_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000847
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Non-accommodating Regular Spikers (naRS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -68.87 mV
Rheobase Current Interval (0.05219, 0.05356] nA
Threshold Current Interval (0.29297, 0.35156] nA
Bias Current (to -80.00 mV) -0.0400 nA
Testing Temperature 34.0 °C
Stability Interval [-2.1875, 15.0] nA
AP 1-2 Amplitude Drop 0.3475 mV
AP 1 Steady State Amplitude Change 0.5382 mV
AP 1 Amplitude 69.3692 mV
AP 1 Width at Half Height 0.6600 ms
AP 1 Width (Peak To Trough) 5.5000 ms
AP 1 Rate of Change Peak to Trough -15.2564 mV/ms
AP 1 AHP Depth 14.5410 mV
AP2 Amplitude 69.0217 mV
AP2 Width at Half Height 0.6600 ms
AP 2 Width (Peak to Trough) 5.9600 ms
AP 2 Rate of Change Peak to Trough -14.0567 mV/ms
AP 2 AHP Depth 14.7561 mV
AP 1-2 Amplitude Change Percent -0.5010 %
AP 1-2 Half Width Change Percent 0.0000 %
AP 1-2 Rate of Change Peak to Trough Percent Change -7.8637 %
AP 1-2 AHP Depth Percent Change 1.4796 %
Input Resistance 283.9902 MΩ
AP 1 Delay Mean 26.2600 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 76.9400 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 50.9600 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean 0.0000 %
Steady State Accommodation Mean 0.0000 %
Accommodation Rate to Steady State 0.0000 %/ms
Accommodation at Steady State Mean -11.9756 %
Accommodation Rate Mean at Steady State 2044.4531 ms
ISI CV 42.6477
ISI Median 53.3700 ms
ISI Burst Mean Change 1.1050 %
Spike Rate (Strong Stimulation) 37.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 9.5000 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 35.0100 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 26.3200 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2094.0600 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 44.5577 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 15761.1 µm2
Number of Stems 9.0
Number of Bifurcations 33.0
Number of Branches 74.0
Overall Width 350.287 µm
Overall Height 376.219 µm
Overall Depth 257.21 µm
Average Diameter 0.952654 µm
Total Length 5017.62 µm
Total Surface 12424.9 µm2
Total Volume 6462.57 µm3
Max Euclidean Distance 283.831 µm
Max Path Distance 324.354 µm
Max Branch Order 5.0
Average Contraction 0.963103
Total Fragmentation 1158.0
Partition Asymmetry 0.37316
Average Rall's Ratio 0.995625
Average Bifurcation Angle Local 37.6696 °
Average Bifurcation Angle Remote 57.3632 °
Fractal Dimension 1.00605
Complexity Summary
State Equations 2551
Optimal Time-Step 0.00775 ms
Relative Complexity 614.17 HH
Model Size
Sections 75
Compartments 253
State Equations 2551
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00775 ms
Optimal Time-Step Error 0.23 %
Optimal Time-Step Benchmark Run Time 614.17 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 1.10 %
Max. Stable Time-Step Benchmark Run Time 1188.89 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 12878 Hz
CVODE Steps Per AP 498
CVODE Benchmark Run Time 558.55 HH
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