Layer 4 Continuous Non-accommodating Martinotti Cell (5)

Model Type:
Cell
Neurolex IDs: Martinotti Cell
Neocortex Layer 4
Keywords: continuous non-accommodating,Layer 4,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, Martinotti
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000846
cNAC187_L4_MC_f8c62d11b0_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000846
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Non-accommodating Regular Spikers (naRS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -69.02 mV
Rheobase Current Interval (0.01579, 0.01648] nA
Threshold Current Interval (0.11719, 0.17578] nA
Bias Current (to -80.00 mV) -0.0162 nA
Testing Temperature 34.0 °C
Stability Interval [-0.625, 15.0] nA
AP 1-2 Amplitude Drop 0.4944 mV
AP 1 Steady State Amplitude Change 0.4216 mV
AP 1 Amplitude 76.8586 mV
AP 1 Width at Half Height 0.5500 ms
AP 1 Width (Peak To Trough) 4.5500 ms
AP 1 Rate of Change Peak to Trough -21.8603 mV/ms
AP 1 AHP Depth 22.6059 mV
AP2 Amplitude 76.3641 mV
AP2 Width at Half Height 0.5600 ms
AP 2 Width (Peak to Trough) 4.8400 ms
AP 2 Rate of Change Peak to Trough -20.4838 mV/ms
AP 2 AHP Depth 22.7773 mV
AP 1-2 Amplitude Change Percent -0.6433 %
AP 1-2 Half Width Change Percent 1.8182 %
AP 1-2 Rate of Change Peak to Trough Percent Change -6.2971 %
AP 1-2 AHP Depth Percent Change 0.7580 %
Input Resistance 666.2839 MΩ
AP 1 Delay Mean 27.6000 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 83.6500 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 56.3350 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -14.2857 %
Steady State Accommodation Mean -14.2857 %
Accommodation Rate to Steady State -0.0145 %/ms
Accommodation at Steady State Mean -20.4586 %
Accommodation Rate Mean at Steady State 1240.5414 ms
ISI CV 18.7631
ISI Median 63.2400 ms
ISI Burst Mean Change 1.0169 %
Spike Rate (Strong Stimulation) 30.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 10.0500 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 39.7200 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 30.0650 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2122.3200 ms
Frequency Filter Type Constant
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 4571.85 µm2
Number of Stems 4.0
Number of Bifurcations 11.0
Number of Branches 25.0
Overall Width 123.349 µm
Overall Height 407.779 µm
Overall Depth 174.49 µm
Average Diameter 0.867431 µm
Total Length 1726.05 µm
Total Surface 3825.14 µm2
Total Volume 1786.76 µm3
Max Euclidean Distance 286.205 µm
Max Path Distance 316.301 µm
Max Branch Order 4.0
Average Contraction 0.969025
Total Fragmentation 584.0
Partition Asymmetry 0.266667
Average Rall's Ratio 1.479
Average Bifurcation Angle Local 48.3593 °
Average Bifurcation Angle Remote 58.2186 °
Fractal Dimension 1.00566
Complexity Summary
State Equations 861
Optimal Time-Step 0.00777 ms
Relative Complexity 201.44 HH
Model Size
Sections 26
Compartments 84
State Equations 861
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00777 ms
Optimal Time-Step Error 0.31 %
Optimal Time-Step Benchmark Run Time 201.44 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 1.05 %
Max. Stable Time-Step Benchmark Run Time 391.33 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 14735 Hz
CVODE Steps Per AP 439
CVODE Benchmark Run Time 196.93 HH
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