Layer 4 Continuous Non-accommodating Martinotti Cell (1)

Model Type:
Cell
Neurolex IDs: Martinotti Cell
Neocortex Layer 4
Keywords: continuous non-accommodating,Layer 4,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, Martinotti
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000842
cNAC187_L4_MC_29457dde26_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000842
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Fast Spikers (FS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -68.82 mV
Rheobase Current Interval (0.05722, 0.05836] nA
Threshold Current Interval (0.23438, 0.29297] nA
Bias Current (to -80.00 mV) -0.0442 nA
Testing Temperature 34.0 °C
Stability Interval [-1.875, 15.0] nA
AP 1-2 Amplitude Drop 0.3094 mV
AP 1 Steady State Amplitude Change 0.3365 mV
AP 1 Amplitude 76.2376 mV
AP 1 Width at Half Height 0.5400 ms
AP 1 Width (Peak To Trough) 2.3900 ms
AP 1 Rate of Change Peak to Trough -39.7334 mV/ms
AP 1 AHP Depth 18.7252 mV
AP2 Amplitude 75.9282 mV
AP2 Width at Half Height 0.5300 ms
AP 2 Width (Peak to Trough) 2.4000 ms
AP 2 Rate of Change Peak to Trough -39.5264 mV/ms
AP 2 AHP Depth 18.9350 mV
AP 1-2 Amplitude Change Percent -0.4058 %
AP 1-2 Half Width Change Percent -1.8519 %
AP 1-2 Rate of Change Peak to Trough Percent Change -0.5210 %
AP 1-2 AHP Depth Percent Change 1.1208 %
Input Resistance 257.2416 MΩ
AP 1 Delay Mean 21.7300 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 66.2600 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 44.9350 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean 0.0000 %
Steady State Accommodation Mean -11.1111 %
Accommodation Rate to Steady State -0.0180 %/ms
Accommodation at Steady State Mean -13.0744 %
Accommodation Rate Mean at Steady State 1892.9931 ms
ISI CV 37.4543
ISI Median 47.5000 ms
ISI Burst Mean Change 1.8190 %
Spike Rate (Strong Stimulation) 41.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 6.8000 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 28.9100 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 23.0550 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2059.9000 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 60.9192 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 18900.2 µm2
Number of Stems 4.0
Number of Bifurcations 32.0
Number of Branches 67.0
Overall Width 280.184 µm
Overall Height 426.195 µm
Overall Depth 175.6 µm
Average Diameter 0.89455 µm
Total Length 4357.94 µm
Total Surface 12075.0 µm2
Total Volume 8687.29 µm3
Max Euclidean Distance 298.046 µm
Max Path Distance 372.557 µm
Max Branch Order 6.0
Average Contraction 0.946584
Total Fragmentation 4351.0
Partition Asymmetry 0.451231
Average Rall's Ratio 0.610345
Average Bifurcation Angle Local 38.157 °
Average Bifurcation Angle Remote 55.3462 °
Fractal Dimension 1.00978
Complexity Summary
State Equations 2181
Optimal Time-Step 0.00771 ms
Relative Complexity 525.05 HH
Model Size
Sections 68
Compartments 216
State Equations 2181
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00771 ms
Optimal Time-Step Error 0.23 %
Optimal Time-Step Benchmark Run Time 525.05 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 1.45 %
Max. Stable Time-Step Benchmark Run Time 1011.94 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 14930 Hz
CVODE Steps Per AP 452
CVODE Benchmark Run Time 517.70 HH
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