Layer 4 Continuous Non-accommodating Large Basket Cell (2)

Model Type:
Cell
Neurolex IDs: Neocortex basket cell
Neocortex Layer 4
Keywords: continuous non-accommodating,Layer 4,Fast-spiking, interneuron, GABAergic, inhibitory, neocortex, rat, somatosensory cortex, large, basket
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000838
cNAC187_L4_LBC_1cf329956f_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000838
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Non-accommodating Regular Spikers (naRS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -68.45 mV
Rheobase Current Interval (0.01373, 0.01465] nA
Threshold Current Interval (0.17578, 0.23438] nA
Bias Current (to -80.00 mV) -0.0205 nA
Testing Temperature 34.0 °C
Stability Interval [-1.25, 15.0] nA
AP 1-2 Amplitude Drop -0.2916 mV
AP 1 Steady State Amplitude Change -0.2209 mV
AP 1 Amplitude 63.1265 mV
AP 1 Width at Half Height 0.8500 ms
AP 1 Width (Peak To Trough) 10.7800 ms
AP 1 Rate of Change Peak to Trough -7.3319 mV/ms
AP 1 AHP Depth 15.9118 mV
AP2 Amplitude 63.4180 mV
AP2 Width at Half Height 0.8600 ms
AP 2 Width (Peak to Trough) 10.7800 ms
AP 2 Rate of Change Peak to Trough -7.3227 mV/ms
AP 2 AHP Depth 15.5203 mV
AP 1-2 Amplitude Change Percent 0.4619 %
AP 1-2 Half Width Change Percent 1.1765 %
AP 1-2 Rate of Change Peak to Trough Percent Change -0.1264 %
AP 1-2 AHP Depth Percent Change -2.4603 %
Input Resistance 597.2869 MΩ
AP 1 Delay Mean 59.5500 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 150.3500 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 91.0750 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean 25.0000 %
Steady State Accommodation Mean 0.0000 %
Accommodation Rate to Steady State 0.0000 %/ms
Accommodation at Steady State Mean -12.3045 %
Accommodation Rate Mean at Steady State 1744.8627 ms
ISI CV 38.2349
ISI Median 95.7200 ms
ISI Burst Mean Change 0.6057 %
Spike Rate (Strong Stimulation) 23.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 21.5300 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 63.5700 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 42.4350 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2175.2500 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 102.0414 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 3649.29 µm2
Number of Stems 6.0
Number of Bifurcations 21.0
Number of Branches 47.0
Overall Width 273.269 µm
Overall Height 412.502 µm
Overall Depth 173.17 µm
Average Diameter 0.832863 µm
Total Length 3302.54 µm
Total Surface 7168.51 µm2
Total Volume 2297.18 µm3
Max Euclidean Distance 273.192 µm
Max Path Distance 309.015 µm
Max Branch Order 4.0
Average Contraction 0.968175
Total Fragmentation 989.0
Partition Asymmetry 0.47619
Average Rall's Ratio 1.49917
Average Bifurcation Angle Local 42.8334 °
Average Bifurcation Angle Remote 49.1521 °
Fractal Dimension 1.00722
Complexity Summary
State Equations 1611
Optimal Time-Step 0.00780 ms
Relative Complexity 375.50 HH
Model Size
Sections 47
Compartments 159
State Equations 1611
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00780 ms
Optimal Time-Step Error 0.06 %
Optimal Time-Step Benchmark Run Time 375.50 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 0.48 %
Max. Stable Time-Step Benchmark Run Time 731.64 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 14989 Hz
CVODE Steps Per AP 384
CVODE Benchmark Run Time 362.42 HH
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