Layer 4 Continuous Non-accommodating Double Bouquet Cell (4)

Model Type:
Cell
Neurolex IDs: Double Bouquet Cell
Neocortex Layer 4
Keywords: continuous non-accommodating,Layer 4,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, double bouquet
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000835
cNAC187_L4_DBC_d99bd73381_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000835
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Fast Spikers (FS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -68.95 mV
Rheobase Current Interval (0.03365, 0.03433] nA
Threshold Current Interval (0.11719, 0.17578] nA
Bias Current (to -80.00 mV) -0.0257 nA
Testing Temperature 34.0 °C
Stability Interval [-0.625, 15.0] nA
AP 1-2 Amplitude Drop 0.6025 mV
AP 1 Steady State Amplitude Change 0.8149 mV
AP 1 Amplitude 82.6307 mV
AP 1 Width at Half Height 0.4900 ms
AP 1 Width (Peak To Trough) 2.1400 ms
AP 1 Rate of Change Peak to Trough -48.7239 mV/ms
AP 1 AHP Depth 21.6384 mV
AP2 Amplitude 82.0282 mV
AP2 Width at Half Height 0.4700 ms
AP 2 Width (Peak to Trough) 2.1600 ms
AP 2 Rate of Change Peak to Trough -48.4017 mV/ms
AP 2 AHP Depth 22.5194 mV
AP 1-2 Amplitude Change Percent -0.7291 %
AP 1-2 Half Width Change Percent -4.0816 %
AP 1-2 Rate of Change Peak to Trough Percent Change -0.6613 %
AP 1-2 AHP Depth Percent Change 4.0711 %
Input Resistance 430.4016 MΩ
AP 1 Delay Mean 20.5400 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 65.3000 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 45.0550 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -11.1111 %
Steady State Accommodation Mean -11.1111 %
Accommodation Rate to Steady State -0.0129 %/ms
Accommodation at Steady State Mean -17.3436 %
Accommodation Rate Mean at Steady State 1536.7269 ms
ISI CV 24.6870
ISI Median 49.0800 ms
ISI Burst Mean Change 1.3181 %
Spike Rate (Strong Stimulation) 40.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 4.9200 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 26.9500 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 22.6650 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2078.5800 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 92.0717 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 9401.36 µm2
Number of Stems 6.0
Number of Bifurcations 30.0
Number of Branches 65.0
Overall Width 196.944 µm
Overall Height 425.34 µm
Overall Depth 189.91 µm
Average Diameter 0.702503 µm
Total Length 3501.12 µm
Total Surface 6982.67 µm2
Total Volume 4267.4 µm3
Max Euclidean Distance 329.828 µm
Max Path Distance 360.249 µm
Max Branch Order 6.0
Average Contraction 0.927096
Total Fragmentation 3048.0
Partition Asymmetry 0.358802
Average Rall's Ratio 0.39875
Average Bifurcation Angle Local 51.263 °
Average Bifurcation Angle Remote 68.6643 °
Fractal Dimension 1.01501
Complexity Summary
State Equations 1781
Optimal Time-Step 0.00775 ms
Relative Complexity 435.09 HH
Model Size
Sections 66
Compartments 176
State Equations 1781
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00775 ms
Optimal Time-Step Error 0.21 %
Optimal Time-Step Benchmark Run Time 435.09 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 1.16 %
Max. Stable Time-Step Benchmark Run Time 842.26 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 14002 Hz
CVODE Steps Per AP 497
CVODE Benchmark Run Time 420.29 HH
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