Layer 4 Continuous Non-accommodating Double Bouquet Cell (3)

Model Type:
Cell
Neurolex IDs: Double Bouquet Cell
Neocortex Layer 4
Keywords: continuous non-accommodating,Layer 4,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, double bouquet
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000834
cNAC187_L4_DBC_cf9508af7b_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000834
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Non-accommodating Regular Spikers (naRS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -68.58 mV
Rheobase Current Interval (0.03754, 0.03845] nA
Threshold Current Interval (0.17578, 0.23438] nA
Bias Current (to -80.00 mV) -0.0345 nA
Testing Temperature 34.0 °C
Stability Interval [-1.25, 15.0] nA
AP 1-2 Amplitude Drop 0.2091 mV
AP 1 Steady State Amplitude Change 0.2981 mV
AP 1 Amplitude 75.9312 mV
AP 1 Width at Half Height 0.5500 ms
AP 1 Width (Peak To Trough) 2.6700 ms
AP 1 Rate of Change Peak to Trough -36.4009 mV/ms
AP 1 AHP Depth 21.2592 mV
AP2 Amplitude 75.7222 mV
AP2 Width at Half Height 0.5500 ms
AP 2 Width (Peak to Trough) 2.6500 ms
AP 2 Rate of Change Peak to Trough -36.7177 mV/ms
AP 2 AHP Depth 21.5797 mV
AP 1-2 Amplitude Change Percent -0.2754 %
AP 1-2 Half Width Change Percent -0.0000 %
AP 1-2 Rate of Change Peak to Trough Percent Change 0.8702 %
AP 1-2 AHP Depth Percent Change 1.5074 %
Input Resistance 339.4130 MΩ
AP 1 Delay Mean 27.6200 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 79.9100 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 52.5950 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean 0.0000 %
Steady State Accommodation Mean 0.0000 %
Accommodation Rate to Steady State 0.0000 %/ms
Accommodation at Steady State Mean -15.3458 %
Accommodation Rate Mean at Steady State 1651.4282 ms
ISI CV 29.0825
ISI Median 56.4500 ms
ISI Burst Mean Change 1.1666 %
Spike Rate (Strong Stimulation) 37.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 7.4700 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 32.0700 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 25.2450 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2109.3600 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 82.4427 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 11222.4 µm2
Number of Stems 4.0
Number of Bifurcations 30.0
Number of Branches 63.0
Overall Width 232.559 µm
Overall Height 665.583 µm
Overall Depth 85.54 µm
Average Diameter 0.914274 µm
Total Length 3212.47 µm
Total Surface 9572.67 µm2
Total Volume 6513.34 µm3
Max Euclidean Distance 523.854 µm
Max Path Distance 588.795 µm
Max Branch Order 6.0
Average Contraction 0.911805
Total Fragmentation 3461.0
Partition Asymmetry 0.406111
Average Rall's Ratio 0.4202
Average Bifurcation Angle Local 54.3384 °
Average Bifurcation Angle Remote 66.6746 °
Fractal Dimension 1.01933
Complexity Summary
State Equations 1661
Optimal Time-Step 0.00763 ms
Relative Complexity 406.85 HH
Model Size
Sections 64
Compartments 164
State Equations 1661
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00763 ms
Optimal Time-Step Error 0.15 %
Optimal Time-Step Benchmark Run Time 406.85 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 0.82 %
Max. Stable Time-Step Benchmark Run Time 775.67 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 13955 Hz
CVODE Steps Per AP 458
CVODE Benchmark Run Time 378.31 HH
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