Layer 4 Continuous Non-accommodating Double Bouquet Cell (2)

Model Type:
Cell
Neurolex IDs: Double Bouquet Cell
Neocortex Layer 4
Keywords: continuous non-accommodating,Layer 4,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, double bouquet
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000833
cNAC187_L4_DBC_c6dae7aa61_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000833
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Non-accommodating Regular Spikers (naRS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -68.80 mV
Rheobase Current Interval (0.03204, 0.03296] nA
Threshold Current Interval (0.17578, 0.23438] nA
Bias Current (to -80.00 mV) -0.0281 nA
Testing Temperature 34.0 °C
Stability Interval [-1.25, 15.0] nA
AP 1-2 Amplitude Drop 0.3660 mV
AP 1 Steady State Amplitude Change 0.4719 mV
AP 1 Amplitude 72.4856 mV
AP 1 Width at Half Height 0.6200 ms
AP 1 Width (Peak To Trough) 5.4000 ms
AP 1 Rate of Change Peak to Trough -16.3494 mV/ms
AP 1 AHP Depth 15.8013 mV
AP2 Amplitude 72.1196 mV
AP2 Width at Half Height 0.6200 ms
AP 2 Width (Peak to Trough) 5.4000 ms
AP 2 Rate of Change Peak to Trough -16.3129 mV/ms
AP 2 AHP Depth 15.9700 mV
AP 1-2 Amplitude Change Percent -0.5049 %
AP 1-2 Half Width Change Percent 0.0000 %
AP 1-2 Rate of Change Peak to Trough Percent Change -0.2236 %
AP 1-2 AHP Depth Percent Change 1.0671 %
Input Resistance 410.7255 MΩ
AP 1 Delay Mean 26.9700 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 79.5900 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 52.9000 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean 0.0000 %
Steady State Accommodation Mean 0.0000 %
Accommodation Rate to Steady State 0.0000 %/ms
Accommodation at Steady State Mean -12.9223 %
Accommodation Rate Mean at Steady State 1578.8233 ms
ISI CV 34.4609
ISI Median 56.1900 ms
ISI Burst Mean Change 1.0642 %
Spike Rate (Strong Stimulation) 35.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 9.6000 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 36.1400 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 27.2550 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2104.6500 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 56.3949 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 7858.86 µm2
Number of Stems 4.0
Number of Bifurcations 41.0
Number of Branches 85.0
Overall Width 233.234 µm
Overall Height 536.828 µm
Overall Depth 102.23 µm
Average Diameter 0.89558 µm
Total Length 3039.64 µm
Total Surface 7986.07 µm2
Total Volume 4035.9 µm3
Max Euclidean Distance 391.243 µm
Max Path Distance 417.02 µm
Max Branch Order 9.0
Average Contraction 0.955082
Total Fragmentation 1032.0
Partition Asymmetry 0.495599
Average Rall's Ratio 0.776667
Average Bifurcation Angle Local 49.0946 °
Average Bifurcation Angle Remote 66.1109 °
Fractal Dimension 1.00559
Complexity Summary
State Equations 1641
Optimal Time-Step 0.00779 ms
Relative Complexity 376.75 HH
Model Size
Sections 86
Compartments 162
State Equations 1641
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00779 ms
Optimal Time-Step Error 0.16 %
Optimal Time-Step Benchmark Run Time 376.75 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 1.15 %
Max. Stable Time-Step Benchmark Run Time 733.19 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 13361 Hz
CVODE Steps Per AP 520
CVODE Benchmark Run Time 358.08 HH
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