Layer 4 Continuous Non-accommodating Bitufted Cell (1)

Model Type:
Cell
Neurolex IDs: Neocortex Layer 4
Keywords: continuous non-accommodating,Layer 4,Rat, somatosensory cortex, bitufted
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000822
cNAC187_L4_BTC_32b27576a9_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000822
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Non-accommodating Regular Spikers (naRS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -69.12 mV
Rheobase Current Interval (0.01991, 0.02060] nA
Threshold Current Interval (0.11719, 0.17578] nA
Bias Current (to -80.00 mV) -0.0166 nA
Testing Temperature 34.0 °C
Stability Interval [-1.25, 15.0] nA
AP 1-2 Amplitude Drop 0.5396 mV
AP 1 Steady State Amplitude Change 0.7223 mV
AP 1 Amplitude 75.7822 mV
AP 1 Width at Half Height 0.6000 ms
AP 1 Width (Peak To Trough) 4.9300 ms
AP 1 Rate of Change Peak to Trough -19.3263 mV/ms
AP 1 AHP Depth 19.4966 mV
AP2 Amplitude 75.2427 mV
AP2 Width at Half Height 0.5900 ms
AP 2 Width (Peak to Trough) 4.9200 ms
AP 2 Rate of Change Peak to Trough -19.3190 mV/ms
AP 2 AHP Depth 19.8069 mV
AP 1-2 Amplitude Change Percent -0.7120 %
AP 1-2 Half Width Change Percent -1.6667 %
AP 1-2 Rate of Change Peak to Trough Percent Change -0.0379 %
AP 1-2 AHP Depth Percent Change 1.5914 %
Input Resistance 655.2143 MΩ
AP 1 Delay Mean 22.5300 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 71.6600 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 49.4050 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -12.5000 %
Steady State Accommodation Mean -12.5000 %
Accommodation Rate to Steady State -0.0130 %/ms
Accommodation at Steady State Mean -20.0817 %
Accommodation Rate Mean at Steady State 1276.1556 ms
ISI CV 19.3110
ISI Median 55.3200 ms
ISI Burst Mean Change 1.1195 %
Spike Rate (Strong Stimulation) 34.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 8.2800 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 34.5200 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 26.7700 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2071.2000 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 116.4781 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 4900.81 µm2
Number of Stems 3.0
Number of Bifurcations 10.0
Number of Branches 22.0
Overall Width 157.639 µm
Overall Height 417.961 µm
Overall Depth 149.15 µm
Average Diameter 1.26171 µm
Total Length 1176.61 µm
Total Surface 4063.59 µm2
Total Volume 2685.1 µm3
Max Euclidean Distance 255.665 µm
Max Path Distance 301.575 µm
Max Branch Order 3.0
Average Contraction 0.954977
Total Fragmentation 905.0
Partition Asymmetry 0.433333
Average Rall's Ratio 0.792143
Average Bifurcation Angle Local 73.7262 °
Average Bifurcation Angle Remote 42.8194 °
Fractal Dimension 1.00874
Complexity Summary
State Equations 611
Optimal Time-Step 0.00779 ms
Relative Complexity 142.12 HH
Model Size
Sections 23
Compartments 59
State Equations 611
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00779 ms
Optimal Time-Step Error 0.19 %
Optimal Time-Step Benchmark Run Time 142.12 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 1.17 %
Max. Stable Time-Step Benchmark Run Time 276.51 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 13558 Hz
CVODE Steps Per AP 515
CVODE Benchmark Run Time 136.08 HH
Website & Images Copyright NeuroML © 2020 For questions: Contact us Links: Search Test |  ModelDB WS