Layer 4 Continuous Non-accommodating Bipolar Cell (5)

Model Type:
Cell
Neurolex IDs: Bipolar Cell
Neocortex Layer 4
Keywords: continuous non-accommodating,Layer 4,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, bipolar
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000821
cNAC187_L4_BP_e936f4d8ba_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000821
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Delayed Regular Spikers (dRS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -67.72 mV
Rheobase Current Interval (0.00809, 0.00830] nA
Threshold Current Interval (0.00000, 0.05310] nA
Bias Current (to -80.00 mV) -0.0119 nA
Testing Temperature 34.0 °C
Stability Interval [0.0, 13.59375] nA
AP 1-2 Amplitude Drop 0.0317 mV
AP 1 Steady State Amplitude Change -0.1988 mV
AP 1 Amplitude 88.2055 mV
AP 1 Width at Half Height 0.4600 ms
AP 1 Width (Peak To Trough) 1.9600 ms
AP 1 Rate of Change Peak to Trough -57.4840 mV/ms
AP 1 AHP Depth 24.4631 mV
AP2 Amplitude 88.1738 mV
AP2 Width at Half Height 0.4500 ms
AP 2 Width (Peak to Trough) 1.9900 ms
AP 2 Rate of Change Peak to Trough -56.5732 mV/ms
AP 2 AHP Depth 24.4069 mV
AP 1-2 Amplitude Change Percent -0.0360 %
AP 1-2 Half Width Change Percent -2.1739 %
AP 1-2 Rate of Change Peak to Trough Percent Change -1.5844 %
AP 1-2 AHP Depth Percent Change -0.2298 %
Input Resistance 969.6342 MΩ
AP 1 Delay Mean 13.7700 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 59.5000 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 46.1750 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -22.2222 %
Steady State Accommodation Mean -33.3333 %
Accommodation Rate to Steady State -0.0285 %/ms
Accommodation at Steady State Mean -31.2430 %
Accommodation Rate Mean at Steady State 1108.7504 ms
ISI CV 11.0362
ISI Median 56.7500 ms
ISI Burst Mean Change 1.9462 %
Spike Rate (Strong Stimulation) 35.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 3.6700 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 26.9000 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 23.7550 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2108.9700 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 54.7905 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 2094.2 µm2
Number of Stems 2.0
Number of Bifurcations 7.0
Number of Branches 15.0
Overall Width 59.7967 µm
Overall Height 796.024 µm
Overall Depth 21.25 µm
Average Diameter 1.07428 µm
Total Length 1150.21 µm
Total Surface 2384.31 µm2
Total Volume 865.918 µm3
Max Euclidean Distance 824.782 µm
Max Path Distance 842.637 µm
Max Branch Order 6.0
Average Contraction 0.990607
Total Fragmentation 256.0
Partition Asymmetry 0.857143
Average Rall's Ratio 1.51667
Average Bifurcation Angle Local 49.0669 °
Average Bifurcation Angle Remote 45.8735 °
Fractal Dimension 1.00184
Complexity Summary
State Equations 601
Optimal Time-Step 0.00550 ms
Relative Complexity 187.50 HH
Model Size
Sections 16
Compartments 58
State Equations 601
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00550 ms
Optimal Time-Step Error 0.12 %
Optimal Time-Step Benchmark Run Time 187.50 HH
 
Maximum Stable Time-Step 0.03125 ms
Maximum Stable Time-Step Error 0.56 %
Max. Stable Time-Step Benchmark Run Time 515.55 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 15338 Hz
CVODE Steps Per AP 429
CVODE Benchmark Run Time 133.11 HH
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