Layer 4 Continuous Non-accommodating Bipolar Cell (3)

Model Type:
Cell
Neurolex IDs: Bipolar Cell
Neocortex Layer 4
Keywords: continuous non-accommodating,Layer 4,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, bipolar, biophysical, continuous non-accommodating bipolar cell, Realistic Network, Neuron or other electrically excitable cell, Synapse, Spatio-temporal Activity Patterns, Detailed Neuronal Models
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000819
cNAC187_L4_BP_a436dc77d5_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000819
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Fast Spikers (FS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -67.97 mV
Rheobase Current Interval (0.00839, 0.00855] nA
Threshold Current Interval (0.00000, 0.04211] nA
Bias Current (to -80.00 mV) -0.0114 nA
Testing Temperature 34.0 °C
Stability Interval [0.0, 10.78125] nA
AP 1-2 Amplitude Drop 0.7566 mV
AP 1 Steady State Amplitude Change 0.5176 mV
AP 1 Amplitude 88.8117 mV
AP 1 Width at Half Height 0.4500 ms
AP 1 Width (Peak To Trough) 1.8400 ms
AP 1 Rate of Change Peak to Trough -61.3280 mV/ms
AP 1 AHP Depth 24.0318 mV
AP2 Amplitude 88.0551 mV
AP2 Width at Half Height 0.4500 ms
AP 2 Width (Peak to Trough) 1.8700 ms
AP 2 Rate of Change Peak to Trough -60.0416 mV/ms
AP 2 AHP Depth 24.2228 mV
AP 1-2 Amplitude Change Percent -0.8520 %
AP 1-2 Half Width Change Percent 0.0000 %
AP 1-2 Rate of Change Peak to Trough Percent Change -2.0975 %
AP 1-2 AHP Depth Percent Change 0.7948 %
Input Resistance 998.9681 MΩ
AP 1 Delay Mean 15.1600 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 61.0000 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 46.3000 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -22.2222 %
Steady State Accommodation Mean -22.2222 %
Accommodation Rate to Steady State -0.0202 %/ms
Accommodation at Steady State Mean -28.7588 %
Accommodation Rate Mean at Steady State 1122.9072 ms
ISI CV 12.2074
ISI Median 55.8350 ms
ISI Burst Mean Change 2.0070 %
Spike Rate (Strong Stimulation) 35.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 3.8600 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 27.3700 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 24.0300 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2124.7700 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 58.9330 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 2094.2 µm2
Number of Stems 2.0
Number of Bifurcations 7.0
Number of Branches 15.0
Overall Width 55.7812 µm
Overall Height 738.221 µm
Overall Depth 64.36 µm
Average Diameter 1.07428 µm
Total Length 1098.84 µm
Total Surface 2259.69 µm2
Total Volume 842.442 µm3
Max Euclidean Distance 766.78 µm
Max Path Distance 779.424 µm
Max Branch Order 6.0
Average Contraction 0.990242
Total Fragmentation 256.0
Partition Asymmetry 0.857143
Average Rall's Ratio 1.51667
Average Bifurcation Angle Local 51.3509 °
Average Bifurcation Angle Remote 46.6736 °
Fractal Dimension 1.00203
Complexity Summary
Relative Complexity 135.26 HH
State Equations 581
Optimal Time-Step 0.00533 ms
Model Size
Sections 16
Compartments 56
State Equations 581
Variable Time-Step Complexity
CVODE Steady State Step Frequency 15222 Hz
CVODE Steps Per AP 481
CVODE Benchmark Run Time 135.26 HH
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