Layer 2/3 Continuous Non-accommodating Nest Basket Cell (4)

Model Type:
Cell
Neurolex IDs: Neocortex basket cell
Neocortex Layer 2
Neocortex Layer 3
Keywords: continuous non-accommodating,Layer 2, Layer 3, Layer 2/3,Fast-spiking, interneuron, GABAergic, inhibitory, neocortex, rat, somatosensory cortex, nest, basket
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000810
cNAC187_L23_NBC_98c1faeec7_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000810
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Non-accommodating Regular Spikers (naRS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -69.25 mV
Rheobase Current Interval (0.02563, 0.02655] nA
Threshold Current Interval (0.17578, 0.23438] nA
Bias Current (to -80.00 mV) -0.0211 nA
Testing Temperature 34.0 °C
Stability Interval [-1.25, 15.0] nA
AP 1-2 Amplitude Drop -0.0605 mV
AP 1 Steady State Amplitude Change 0.3709 mV
AP 1 Amplitude 67.9222 mV
AP 1 Width at Half Height 0.7100 ms
AP 1 Width (Peak To Trough) 6.0600 ms
AP 1 Rate of Change Peak to Trough -14.5874 mV/ms
AP 1 AHP Depth 20.4776 mV
AP2 Amplitude 67.9827 mV
AP2 Width at Half Height 0.7200 ms
AP 2 Width (Peak to Trough) 6.2200 ms
AP 2 Rate of Change Peak to Trough -14.1877 mV/ms
AP 2 AHP Depth 20.2647 mV
AP 1-2 Amplitude Change Percent 0.0890 %
AP 1-2 Half Width Change Percent 1.4085 %
AP 1-2 Rate of Change Peak to Trough Percent Change -2.7404 %
AP 1-2 AHP Depth Percent Change -1.0398 %
Input Resistance 508.4144 MΩ
AP 1 Delay Mean 25.8300 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 78.8500 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 53.3100 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean 0.0000 %
Steady State Accommodation Mean 0.0000 %
Accommodation Rate to Steady State 0.0000 %/ms
Accommodation at Steady State Mean -20.8753 %
Accommodation Rate Mean at Steady State 1276.1613 ms
ISI CV 18.4883
ISI Median 59.9200 ms
ISI Burst Mean Change 1.0939 %
Spike Rate (Strong Stimulation) 32.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 9.6300 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 37.6300 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 28.4550 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2113.4800 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 76.2533 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 8107.62 µm2
Number of Stems 8.0
Number of Bifurcations 24.0
Number of Branches 55.0
Overall Width 213.205 µm
Overall Height 229.473 µm
Overall Depth 130.77 µm
Average Diameter 0.946172 µm
Total Length 2526.26 µm
Total Surface 5866.76 µm2
Total Volume 3379.46 µm3
Max Euclidean Distance 201.159 µm
Max Path Distance 223.216 µm
Max Branch Order 6.0
Average Contraction 0.978242
Total Fragmentation 796.0
Partition Asymmetry 0.441667
Average Rall's Ratio 1.35625
Average Bifurcation Angle Local 61.6111 °
Average Bifurcation Angle Remote 68.4929 °
Fractal Dimension 1.0033
Complexity Summary
State Equations 1261
Optimal Time-Step 0.00760 ms
Relative Complexity 295.46 HH
Model Size
Sections 56
Compartments 124
State Equations 1261
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00760 ms
Optimal Time-Step Error 0.10 %
Optimal Time-Step Benchmark Run Time 295.46 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 1.01 %
Max. Stable Time-Step Benchmark Run Time 560.82 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 14287 Hz
CVODE Steps Per AP 483
CVODE Benchmark Run Time 282.05 HH
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