Layer 2/3 Continuous Non-accommodating Nest Basket Cell (3)

Model Type:
Cell
Neurolex IDs: Neocortex basket cell
Neocortex Layer 2
Neocortex Layer 3
Keywords: continuous non-accommodating,Layer 2, Layer 3, Layer 2/3,Fast-spiking, interneuron, GABAergic, inhibitory, neocortex, rat, somatosensory cortex, nest, basket
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000809
cNAC187_L23_NBC_9004ab9cec_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000809
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Non-accommodating Regular Spikers (naRS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -68.79 mV
Rheobase Current Interval (0.01556, 0.01648] nA
Threshold Current Interval (0.17578, 0.23438] nA
Bias Current (to -80.00 mV) -0.0180 nA
Testing Temperature 34.0 °C
Stability Interval [-1.25, 15.0] nA
AP 1-2 Amplitude Drop -0.7208 mV
AP 1 Steady State Amplitude Change -0.6364 mV
AP 1 Amplitude 59.4102 mV
AP 1 Width at Half Height 1.0100 ms
AP 1 Width (Peak To Trough) 10.4400 ms
AP 1 Rate of Change Peak to Trough -7.2452 mV/ms
AP 1 AHP Depth 16.2292 mV
AP2 Amplitude 60.1310 mV
AP2 Width at Half Height 1.0400 ms
AP 2 Width (Peak to Trough) 10.4500 ms
AP 2 Rate of Change Peak to Trough -7.2281 mV/ms
AP 2 AHP Depth 15.4024 mV
AP 1-2 Amplitude Change Percent 1.2132 %
AP 1-2 Half Width Change Percent 2.9703 %
AP 1-2 Rate of Change Peak to Trough Percent Change -0.2357 %
AP 1-2 AHP Depth Percent Change -5.0944 %
Input Resistance 645.5639 MΩ
AP 1 Delay Mean 49.0300 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 128.1800 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 79.4450 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -20.0000 %
Steady State Accommodation Mean 0.0000 %
Accommodation Rate to Steady State 0.0000 %/ms
Accommodation at Steady State Mean -13.8673 %
Accommodation Rate Mean at Steady State 1594.4268 ms
ISI CV 31.9450
ISI Median 84.5100 ms
ISI Burst Mean Change 0.7454 %
Spike Rate (Strong Stimulation) 25.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 17.9300 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 55.8500 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 38.3700 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2144.9400 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 100.1927 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 3648.35 µm2
Number of Stems 9.0
Number of Bifurcations 26.0
Number of Branches 60.0
Overall Width 260.014 µm
Overall Height 234.576 µm
Overall Depth 146.74 µm
Average Diameter 0.82778 µm
Total Length 3095.13 µm
Total Surface 6678.78 µm2
Total Volume 2248.94 µm3
Max Euclidean Distance 194.256 µm
Max Path Distance 217.85 µm
Max Branch Order 7.0
Average Contraction 0.968995
Total Fragmentation 886.0
Partition Asymmetry 0.367333
Average Rall's Ratio 1.36786
Average Bifurcation Angle Local 37.8062 °
Average Bifurcation Angle Remote 50.7485 °
Fractal Dimension 1.00505
Complexity Summary
State Equations 1611
Optimal Time-Step 0.00764 ms
Relative Complexity 384.53 HH
Model Size
Sections 61
Compartments 159
State Equations 1611
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00764 ms
Optimal Time-Step Error 0.09 %
Optimal Time-Step Benchmark Run Time 384.53 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 0.90 %
Max. Stable Time-Step Benchmark Run Time 734.47 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 14975 Hz
CVODE Steps Per AP 389
CVODE Benchmark Run Time 364.49 HH
Website & Images Copyright NeuroML © 2019 For questions: Contact us Links: Search Test |  ModelDB WS