Layer 2/3 Continuous Non-accommodating Nest Basket Cell (2)

Model Type:
Cell
Neurolex IDs: Neocortex basket cell
Neocortex Layer 2
Neocortex Layer 3
Keywords: continuous non-accommodating,Layer 2, Layer 3, Layer 2/3,Fast-spiking, interneuron, GABAergic, inhibitory, neocortex, rat, somatosensory cortex, nest, basket
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000808
cNAC187_L23_NBC_7f97b8e83f_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000808
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Non-accommodating Regular Spikers (naRS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -69.09 mV
Rheobase Current Interval (0.03319, 0.03433] nA
Threshold Current Interval (0.23438, 0.29297] nA
Bias Current (to -80.00 mV) -0.0279 nA
Testing Temperature 34.0 °C
Stability Interval [-1.875, 15.0] nA
AP 1-2 Amplitude Drop -0.0523 mV
AP 1 Steady State Amplitude Change 0.2021 mV
AP 1 Amplitude 64.2573 mV
AP 1 Width at Half Height 0.7900 ms
AP 1 Width (Peak To Trough) 7.1800 ms
AP 1 Rate of Change Peak to Trough -11.5910 mV/ms
AP 1 AHP Depth 18.9663 mV
AP2 Amplitude 64.3096 mV
AP2 Width at Half Height 0.7900 ms
AP 2 Width (Peak to Trough) 7.2000 ms
AP 2 Rate of Change Peak to Trough -11.5474 mV/ms
AP 2 AHP Depth 18.8319 mV
AP 1-2 Amplitude Change Percent 0.0813 %
AP 1-2 Half Width Change Percent 0.0000 %
AP 1-2 Rate of Change Peak to Trough Percent Change -0.3762 %
AP 1-2 AHP Depth Percent Change -0.7086 %
Input Resistance 396.3799 MΩ
AP 1 Delay Mean 30.9300 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 89.3400 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 58.6750 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -14.2857 %
Steady State Accommodation Mean -14.2857 %
Accommodation Rate to Steady State -0.0162 %/ms
Accommodation at Steady State Mean -16.4609 %
Accommodation Rate Mean at Steady State 1376.7481 ms
ISI CV 24.7820
ISI Median 63.9000 ms
ISI Burst Mean Change 0.9074 %
Spike Rate (Strong Stimulation) 31.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 11.3800 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 41.2000 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 30.2950 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2111.3700 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 45.3369 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 10371.7 µm2
Number of Stems 9.0
Number of Bifurcations 23.0
Number of Branches 54.0
Overall Width 247.053 µm
Overall Height 308.542 µm
Overall Depth 255.4 µm
Average Diameter 1.08313 µm
Total Length 3144.14 µm
Total Surface 8457.76 µm2
Total Volume 4664.04 µm3
Max Euclidean Distance 237.901 µm
Max Path Distance 259.807 µm
Max Branch Order 3.0
Average Contraction 0.967427
Total Fragmentation 854.0
Partition Asymmetry 0.26087
Average Rall's Ratio 1.09469
Average Bifurcation Angle Local 16.5164 °
Average Bifurcation Angle Remote 49.9464 °
Fractal Dimension 1.00337
Complexity Summary
State Equations 1591
Optimal Time-Step 0.00762 ms
Relative Complexity 385.18 HH
Model Size
Sections 57
Compartments 157
State Equations 1591
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00762 ms
Optimal Time-Step Error 0.20 %
Optimal Time-Step Benchmark Run Time 385.18 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 1.23 %
Max. Stable Time-Step Benchmark Run Time 733.16 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 14111 Hz
CVODE Steps Per AP 449
CVODE Benchmark Run Time 358.84 HH
Website & Images Copyright NeuroML © 2020 For questions: Contact us Links: Search Test |  ModelDB WS