Layer 2/3 Continuous Non-accommodating Martinotti Cell (4)

Model Type:
Cell
Neurolex IDs: Neocortex Layer 2
Neocortex Layer 3
Martinotti Cell
Keywords: continuous non-accommodating,Layer 2, Layer 3, Layer 2/3,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, Martinotti
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000805
cNAC187_L23_MC_4a274f4915_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000805
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Non-accommodating Regular Spikers (naRS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -68.01 mV
Rheobase Current Interval (0.02632, 0.02747] nA
Threshold Current Interval (0.23438, 0.29297] nA
Bias Current (to -80.00 mV) -0.0395 nA
Testing Temperature 34.0 °C
Stability Interval [-2.5, 15.0] nA
AP 1-2 Amplitude Drop -0.2708 mV
AP 1 Steady State Amplitude Change -0.0991 mV
AP 1 Amplitude 67.1088 mV
AP 1 Width at Half Height 0.6600 ms
AP 1 Width (Peak To Trough) 6.0700 ms
AP 1 Rate of Change Peak to Trough -12.5780 mV/ms
AP 1 AHP Depth 9.2398 mV
AP2 Amplitude 67.3796 mV
AP2 Width at Half Height 0.6700 ms
AP 2 Width (Peak to Trough) 5.9100 ms
AP 2 Rate of Change Peak to Trough -12.9059 mV/ms
AP 2 AHP Depth 8.8945 mV
AP 1-2 Amplitude Change Percent 0.4035 %
AP 1-2 Half Width Change Percent 1.5152 %
AP 1-2 Rate of Change Peak to Trough Percent Change 2.6069 %
AP 1-2 AHP Depth Percent Change -3.7380 %
Input Resistance 332.4118 MΩ
AP 1 Delay Mean 60.2300 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 136.5900 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 76.4050 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean 20.0000 %
Steady State Accommodation Mean 0.0000 %
Accommodation Rate to Steady State 0.0000 %/ms
Accommodation at Steady State Mean -99.6281 %
Accommodation Rate Mean at Steady State 21179463.4239 ms
ISI CV 118.1818
ISI Median 76.3300 ms
ISI Burst Mean Change 0.1179 %
Spike Rate (Strong Stimulation) 32.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 19.6700 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 50.3500 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 31.7950 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2117.2800 ms
Frequency Filter Type Constant
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 6189.31 µm2
Number of Stems 6.0
Number of Bifurcations 66.0
Number of Branches 137.0
Overall Width 252.832 µm
Overall Height 371.928 µm
Overall Depth 308.45 µm
Average Diameter 0.749064 µm
Total Length 7043.17 µm
Total Surface 15207.5 µm2
Total Volume 4281.65 µm3
Max Euclidean Distance 257.81 µm
Max Path Distance 403.485 µm
Max Branch Order 8.0
Average Contraction 0.976126
Total Fragmentation 1492.0
Partition Asymmetry 0.292063
Average Rall's Ratio 0.965333
Average Bifurcation Angle Local 40.0151 °
Average Bifurcation Angle Remote 45.9687 °
Fractal Dimension 1.00414
Complexity Summary
State Equations 3641
Optimal Time-Step 0.00761 ms
Relative Complexity 808.74 HH
Model Size
Sections 138
Compartments 362
State Equations 3641
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00761 ms
Optimal Time-Step Error 0.09 %
Optimal Time-Step Benchmark Run Time 808.74 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 0.66 %
Max. Stable Time-Step Benchmark Run Time 1537.85 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 14974 Hz
CVODE Steps Per AP 337
CVODE Benchmark Run Time 742.14 HH
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