Layer 2/3 Continuous Non-accommodating Martinotti Cell (1)

Model Type:
Cell
Neurolex IDs: Neocortex Layer 2
Neocortex Layer 3
Martinotti Cell
Keywords: continuous non-accommodating,Layer 2, Layer 3, Layer 2/3,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, Martinotti
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000802
cNAC187_L23_MC_2c0a7badf4_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000802
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Non-accommodating Regular Spikers (naRS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -68.70 mV
Rheobase Current Interval (0.02655, 0.02747] nA
Threshold Current Interval (0.17578, 0.23438] nA
Bias Current (to -80.00 mV) -0.0266 nA
Testing Temperature 34.0 °C
Stability Interval [-1.875, 15.0] nA
AP 1-2 Amplitude Drop 0.1220 mV
AP 1 Steady State Amplitude Change 0.3757 mV
AP 1 Amplitude 75.1265 mV
AP 1 Width at Half Height 0.5800 ms
AP 1 Width (Peak To Trough) 4.0400 ms
AP 1 Rate of Change Peak to Trough -22.5211 mV/ms
AP 1 AHP Depth 15.8586 mV
AP2 Amplitude 75.0045 mV
AP2 Width at Half Height 0.5700 ms
AP 2 Width (Peak to Trough) 4.2300 ms
AP 2 Rate of Change Peak to Trough -21.5425 mV/ms
AP 2 AHP Depth 16.1203 mV
AP 1-2 Amplitude Change Percent -0.1623 %
AP 1-2 Half Width Change Percent -1.7241 %
AP 1-2 Rate of Change Peak to Trough Percent Change -4.3451 %
AP 1-2 AHP Depth Percent Change 1.6500 %
Input Resistance 446.2814 MΩ
AP 1 Delay Mean 30.6000 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 87.9900 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 57.6550 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -14.2857 %
Steady State Accommodation Mean 0.0000 %
Accommodation Rate to Steady State 0.0000 %/ms
Accommodation at Steady State Mean -13.0786 %
Accommodation Rate Mean at Steady State 1551.6793 ms
ISI CV 33.7341
ISI Median 61.3050 ms
ISI Burst Mean Change 0.9235 %
Spike Rate (Strong Stimulation) 33.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 10.5400 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 38.7100 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 28.8550 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2088.1500 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 127.0079 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 7413.38 µm2
Number of Stems 3.0
Number of Bifurcations 19.0
Number of Branches 40.0
Overall Width 222.401 µm
Overall Height 485.346 µm
Overall Depth 265.68 µm
Average Diameter 0.949046 µm
Total Length 2868.54 µm
Total Surface 7205.57 µm2
Total Volume 3493.55 µm3
Max Euclidean Distance 322.168 µm
Max Path Distance 363.404 µm
Max Branch Order 5.0
Average Contraction 0.969874
Total Fragmentation 780.0
Partition Asymmetry 0.435088
Average Rall's Ratio 0.933
Average Bifurcation Angle Local 49.4325 °
Average Bifurcation Angle Remote 72.3296 °
Fractal Dimension 1.0038
Complexity Summary
State Equations 1471
Optimal Time-Step 0.00765 ms
Relative Complexity 343.13 HH
Model Size
Sections 41
Compartments 145
State Equations 1471
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00765 ms
Optimal Time-Step Error 0.22 %
Optimal Time-Step Benchmark Run Time 343.13 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 1.17 %
Max. Stable Time-Step Benchmark Run Time 656.41 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 14035 Hz
CVODE Steps Per AP 450
CVODE Benchmark Run Time 320.05 HH
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