Layer 2/3 Continuous Non-accommodating Chandelier Cell (3)

Model Type:
Cell
Neurolex IDs: Neocortex Layer 2
Neocortex Layer 3
Chandelier Cell
Keywords: continuous non-accommodating,Layer 2, Layer 3, Layer 2/3,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, chandelier
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000794
cNAC187_L23_ChC_85582ca6d2_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000794
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Non-accommodating Regular Spikers (naRS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -68.65 mV
Rheobase Current Interval (0.02197, 0.02289] nA
Threshold Current Interval (0.17578, 0.23438] nA
Bias Current (to -80.00 mV) -0.0259 nA
Testing Temperature 34.0 °C
Stability Interval [-1.5625, 15.0] nA
AP 1-2 Amplitude Drop 0.0405 mV
AP 1 Steady State Amplitude Change 0.1685 mV
AP 1 Amplitude 69.0653 mV
AP 1 Width at Half Height 0.6800 ms
AP 1 Width (Peak To Trough) 7.4900 ms
AP 1 Rate of Change Peak to Trough -11.5791 mV/ms
AP 1 AHP Depth 17.6623 mV
AP2 Amplitude 69.0248 mV
AP2 Width at Half Height 0.6800 ms
AP 2 Width (Peak to Trough) 7.5100 ms
AP 2 Rate of Change Peak to Trough -11.5441 mV/ms
AP 2 AHP Depth 17.6712 mV
AP 1-2 Amplitude Change Percent -0.0587 %
AP 1-2 Half Width Change Percent 0.0000 %
AP 1-2 Rate of Change Peak to Trough Percent Change -0.3027 %
AP 1-2 AHP Depth Percent Change 0.0501 %
Input Resistance 451.0364 MΩ
AP 1 Delay Mean 40.9700 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 111.5300 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 70.8300 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -16.6667 %
Steady State Accommodation Mean 0.0000 %
Accommodation Rate to Steady State 0.0000 %/ms
Accommodation at Steady State Mean -13.4598 %
Accommodation Rate Mean at Steady State 1427.0719 ms
ISI CV 31.3277
ISI Median 75.6600 ms
ISI Burst Mean Change 0.7653 %
Spike Rate (Strong Stimulation) 27.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 14.6600 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 49.0200 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 34.8200 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2136.0500 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 62.4148 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 6056.82 µm2
Number of Stems 6.0
Number of Bifurcations 18.0
Number of Branches 41.0
Overall Width 175.186 µm
Overall Height 433.695 µm
Overall Depth 72.84 µm
Average Diameter 0.840638 µm
Total Length 2846.3 µm
Total Surface 7820.92 µm2
Total Volume 3354.09 µm3
Max Euclidean Distance 297.817 µm
Max Path Distance 368.141 µm
Max Branch Order 5.0
Average Contraction 0.935963
Total Fragmentation 2592.0
Partition Asymmetry 0.518519
Average Rall's Ratio 1.07687
Average Bifurcation Angle Local 15.2306 °
Average Bifurcation Angle Remote 50.8124 °
Fractal Dimension 1.01336
Complexity Summary
State Equations 1441
Optimal Time-Step 0.00779 ms
Relative Complexity 334.35 HH
Model Size
Sections 42
Compartments 142
State Equations 1441
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00779 ms
Optimal Time-Step Error 0.12 %
Optimal Time-Step Benchmark Run Time 334.35 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 0.83 %
Max. Stable Time-Step Benchmark Run Time 650.98 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 14771 Hz
CVODE Steps Per AP 427
CVODE Benchmark Run Time 326.10 HH
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