Layer 1 Continuous Non-accommodating Small Axon Cell (1)

Model Type:
Cell
Neurolex IDs: Neocortex Layer 1
Keywords: continuous non-accommodating,Layer 1,Rat, somatosensory cortex, neocortex, small axon
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000777
cNAC187_L1_SLAC_16735ed026_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000777
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Non-accommodating Regular Spikers (naRS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -68.12 mV
Rheobase Current Interval (0.02335, 0.02472] nA
Threshold Current Interval (0.29297, 0.35156] nA
Bias Current (to -80.00 mV) -0.0355 nA
Testing Temperature 34.0 °C
Stability Interval [-3.4375, 15.0] nA
AP 1-2 Amplitude Drop -0.0524 mV
AP 1 Steady State Amplitude Change -0.0065 mV
AP 1 Amplitude 60.4734 mV
AP 1 Width at Half Height 0.8600 ms
AP 1 Width (Peak To Trough) 14.6000 ms
AP 1 Rate of Change Peak to Trough -4.9104 mV/ms
AP 1 AHP Depth 11.2187 mV
AP2 Amplitude 60.5258 mV
AP2 Width at Half Height 0.8600 ms
AP 2 Width (Peak to Trough) 14.6700 ms
AP 2 Rate of Change Peak to Trough -4.8742 mV/ms
AP 2 AHP Depth 10.9791 mV
AP 1-2 Amplitude Change Percent 0.0867 %
AP 1-2 Half Width Change Percent 0.0000 %
AP 1-2 Rate of Change Peak to Trough Percent Change -0.7370 %
AP 1-2 AHP Depth Percent Change -2.1359 %
Input Resistance 366.3004 MΩ
AP 1 Delay Mean 61.3200 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 147.6600 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 86.3850 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean 25.0000 %
Steady State Accommodation Mean 25.0000 %
Accommodation Rate to Steady State 0.1693 %/ms
Accommodation at Steady State Mean -99.6465 %
Accommodation Rate Mean at Steady State 10227436.7567 ms
ISI CV 65.8201
ISI Median 87.9800 ms
ISI Burst Mean Change 0.1042 %
Spike Rate (Strong Stimulation) 26.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 21.3800 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 58.7100 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 38.0500 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2140.5900 ms
Frequency Filter Type Constant
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 6687.78 µm2
Number of Stems 5.0
Number of Bifurcations 15.0
Number of Branches 34.0
Overall Width 311.495 µm
Overall Height 416.015 µm
Overall Depth 214.6 µm
Average Diameter 1.13566 µm
Total Length 3504.51 µm
Total Surface 12043.4 µm2
Total Volume 5142.96 µm3
Max Euclidean Distance 342.262 µm
Max Path Distance 405.801 µm
Max Branch Order 3.0
Average Contraction 0.919144
Total Fragmentation 1807.0
Partition Asymmetry 0.377778
Average Rall's Ratio 1.76417
Average Bifurcation Angle Local 42.9453 °
Average Bifurcation Angle Remote 79.821 °
Fractal Dimension 1.01274
Complexity Summary
State Equations 1751
Optimal Time-Step 0.00775 ms
Relative Complexity 389.58 HH
Model Size
Sections 35
Compartments 173
State Equations 1751
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00775 ms
Optimal Time-Step Error 0.09 %
Optimal Time-Step Benchmark Run Time 389.58 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 0.69 %
Max. Stable Time-Step Benchmark Run Time 754.09 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 14310 Hz
CVODE Steps Per AP 318
CVODE Benchmark Run Time 346.99 HH
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